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Published on: July 6, 2013
Cytomegalovirus antibody in the elderly
L A Weymouth1, I H Gomolin, T Brennan
1Department of Pathology, Hartford Hospital, Conn.
Abstract:
Presence of cytomegalovirus (CMV) specific immunoglobulin M (IgM) is generally considered strong evidence of current or recent CMV infection. Sera from 110 elderly individuals (age range 61-100 years) were compared with sera from 87 younger individuals (age range 16-47 years). Prevalence of CMV IgM was found to be 30% in the older group (mean age 83 years) and only 6% in the younger group (mean age 29 years). In spite of increased CMV antibody levels, none of the elderly individuals were symptomatic. Viral cultures of urine from 72 elderly individuals were negative for CMV. These results suggest that the presence of CMV-specific IgM must be interpreted with caution in an elderly population.
Insights
Cytomegalovirus (CMV) immunoglobulin M (IgM) presence is often linked to recent infection. However, in elderly individuals, CMV IgM detection may not indicate active infection and requires cautious interpretation.
Area of Science:
- Virology
- Immunology
- Gerontology
Background:
- Cytomegalovirus (CMV) specific immunoglobulin M (IgM) is typically a marker for acute or recent infection.
- Age-related changes in the immune system may affect the interpretation of serological markers.
Purpose of the Study:
- To investigate the prevalence and significance of CMV-specific IgM in an elderly population compared to younger adults.
- To determine if CMV IgM positivity in the elderly correlates with active infection.
Main Methods:
- Sera from 110 elderly individuals (61-100 years) and 87 younger individuals (16-47 years) were tested for CMV IgM.
- Clinical symptoms and viral cultures (urine) were assessed in the elderly cohort.
Main Results:
- CMV IgM prevalence was significantly higher in the elderly group (30%) compared to the younger group (6%).
- None of the elderly individuals with positive CMV IgM results were symptomatic.
- Urine viral cultures were negative for CMV in 72 elderly participants.
Conclusions:
- The presence of CMV-specific IgM in elderly individuals should be interpreted with caution.
- Elevated CMV IgM levels in the elderly may not necessarily indicate a current or recent CMV infection.
