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In Vitro Model of Human Cutaneous Hypertrophic Scarring using Macromolecular Crowding
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Treatment of keloids and hypertrophic scars using topical and intralesional mitomycin C

S-H Seo1, H-W Sung

  • 1Department of Dermatology and Medical Research Institute, Yangsan Pusan National University Hospital, Yangsan, Korea. soesh97@lycos.co.kr

Journal of the European Academy of Dermatology and Venereology : JEADV
|June 10, 2011
PubMed
Abstract

Insights

Topical mitomycin C (MMC) is effective for keloid and hypertrophic scar (HTS) treatment after surgical removal. Intralesional MMC, however, worsened these scar types, indicating its ineffectiveness.

Area of Science:

  • Dermatology
  • Wound Healing
  • Pharmacology

Background:

  • Keloids and hypertrophic scars (HTS) result from excessive fibrous tissue growth.
  • Current treatments for keloids and HTS lack a gold standard, with frequent recurrence.
  • Antineoplastic agents are being investigated due to the invasive nature of these scars.

Purpose of the Study:

  • To evaluate the effectiveness of topical and intralesional mitomycin C (MMC) for keloid and HTS treatment.
  • To assess patient satisfaction and adverse effects of MMC therapy.
  • To compare the outcomes of topical versus intralesional MMC application.

Main Methods:

  • Nine patients with keloids/HTS underwent shaving excision followed by topical MMC (1 mg/mL) application for 3 minutes.
  • Vancouver Scar Scale, patient satisfaction, and adverse events were monitored for 6 months.
  • Two patients received intralesional MMC (1 mg/mL) to assess its effect on keloid regression.

Main Results:

  • Topical MMC post-excision showed positive outcomes, with 6 of 9 patients highly satisfied.
  • No patients reported disappointment with topical MMC treatment.
  • Intralesional MMC administration yielded poor results, with both patients experiencing worsening and increased ulceration.

Conclusions:

  • Topical mitomycin C application after shaving excision is a safe and effective treatment for keloids and HTS.
  • Intralesional mitomycin C therapy proved detrimental, aggravating both keloid and HTS lesions.
  • Further research into topical MMC applications for scar management is warranted.

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