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Encoded peptide libraries and the discovery of new cell binding ligands

Nina Svensen1, Juan José Díaz-Mochón, Mark Bradley

  • 1School of Chemistry, EastChem, The University of Edinburgh, Joseph Black Building, West Mains Road, Edinburgh, EH9 3JJ, UK.

Chemical Communications (Cambridge, England)
|June 10, 2011
PubMed

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Ligand Binding Sites02:40

Ligand Binding Sites

Proteins are dynamic macromolecules that carry out a wide variety of essential processes; however, the activities of most proteins depend on their interactions with other molecules or ions, known as ligands.
Protein-ligand interactions are quite specific; even though numerous potential ligands surround a cellular protein at any given time, only a particular ligand can bind to that protein. Moreover, a ligand binds only to a dedicated area on the surface of the protein, known as the...