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Related Concept Videos

2D NMR: Overview of Homonuclear Correlation Techniques01:16

2D NMR: Overview of Homonuclear Correlation Techniques

Homonuclear correlation spectroscopy (COSY) is a powerful technique used in Nuclear Magnetic Resonance (NMR) spectroscopy to study the correlations between nuclei of the same type within a molecule. It provides information about scalar couplings between adjacent nuclei, which helps determine connectivity and structural information. There are several COSY variants, each with its unique strengths and experimental parameters.
COSY90 is the standard two-dimensional (2D) COSY experiment that...
NMR Spectroscopy: Spin–Spin Coupling01:08

NMR Spectroscopy: Spin–Spin Coupling

The spin state of an NMR-active nucleus can have a slight effect on its immediate electronic environment. This effect propagates through the intervening bonds and affects the electronic environments of NMR-active nuclei up to three bonds away; occasionally, even farther. This phenomenon is called spin–spin coupling or J-coupling. Coupling interactions are mutual and result in small changes in the absorption frequencies of both nuclei involved. While nuclei of the same element are involved in...
Double Resonance Techniques: Overview01:12

Double Resonance Techniques: Overview

Double resonance techniques in Nuclear Magnetic Resonance (NMR) spectroscopy involve the simultaneous application of two different frequencies or radiofrequency pulses to manipulate and observe two distinct nuclear spins. One important application of double resonance is spin decoupling, which selectively suppresses coupling with one type of nucleus while observing the NMR signal from another nucleus, simplifying the spectrum and enhancing resolution.
Spin decoupling is usually achieved by...
2D NMR: Overview of Heteronuclear Correlation Techniques01:18

2D NMR: Overview of Heteronuclear Correlation Techniques

Heteronuclear correlation spectroscopy is an analytical technique that investigates the coupling between different types of nuclei, often a proton and an X-nucleus, such as carbon-13 or nitrogen-15. This method is commonly used in nuclear magnetic resonance (NMR) spectroscopy to gain insights into complex chemical compounds' structural and compositional aspects. A typical heteronuclear correlation spectrum displays X-nucleus chemical shifts on one axis and a proton spectrum on the other axis.
NMR Spectrometers: Overview01:20

NMR Spectrometers: Overview

NMR spectrometers consist of a strong magnet, a radiofrequency transmitter, and a detector attached to a computer console for recording spectra of samples containing NMR-active nuclei. In first-generation NMR instruments called continuous-wave spectrometers, the resonance frequencies of the nuclei are determined by frequency-sweep or field-sweep methods. The magnetic field strength is fixed and the rf signal is swept in the former, while the radiofrequency signal is fixed and the magnetic field...
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Nuclear magnetic resonance (NMR) is a phenomenon exhibited by certain nuclei that can absorb characteristic radio frequency radiation under certain conditions. NMR has been extensively applied in molecular spectroscopy and medical diagnostic imaging. In both these applications, the molecule or subject under study is placed in a magnetic field and irradiated with radio frequency energy.
NMR spectroscopy generates a spectrum where the characteristic absorption frequencies of the sample are...

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Atomic Scale Structural Studies of Macromolecular Assemblies by Solid-state Nuclear Magnetic Resonance Spectroscopy
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Atomic Scale Structural Studies of Macromolecular Assemblies by Solid-state Nuclear Magnetic Resonance Spectroscopy

Published on: September 17, 2017

Probing quadrupolar nuclei by solid-state NMR spectroscopy: recent advances.

Christian Fernandez1, Marek Pruski

  • 1Université de Caen, CNRS, Caen, France. christian.fernandez@ensicaen.fr

Topics in Current Chemistry
|June 10, 2011
PubMed
Summary
This summary is machine-generated.

Solid-state nuclear magnetic resonance (NMR) has advanced significantly for quadrupolar nuclei, enabling detailed molecular structural and dynamic insights. This review covers key developments and high-resolution techniques for both integer and half-integer spin quadrupolar nuclei.

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Area of Science:

  • Solid-state Nuclear Magnetic Resonance (NMR) Spectroscopy
  • Quantum Mechanics
  • Materials Science

Background:

  • Quadrupolar nuclei, prevalent in many chemical and biological systems, present unique challenges in NMR spectroscopy due to strong quadrupolar interactions.
  • Traditional NMR methods often struggle to provide high-resolution structural and dynamic information for these nuclei.
  • Recent advancements have significantly enhanced the capabilities of solid-state NMR for quadrupolar nuclei.

Purpose of the Study:

  • To provide a comprehensive review of the progress in solid-state NMR of quadrupolar nuclei over the past two decades.
  • To elucidate the effects of first- and second-order quadrupolar interactions on NMR spectra.
  • To compare and contrast various high-resolution techniques for half-integer spin quadrupolar nuclei.

Main Methods:

  • Description of first- and second-order quadrupolar interactions and their spectral impact.
  • Explanation of techniques for exciting single- and multiple-quantum coherences.
  • Overview of high-resolution methods: Double Rotation (DOR), Dynamic Angle Spinning (DAS), Multiple-Quantum Magic Angle Spinning (MQMAS), and Satellite Transition Magic Angle Spinning (STMAS).
  • Discussion of spectral processing and analysis methods.
  • Review of heteronuclear and homonuclear correlation techniques.

Main Results:

  • Demonstration of remarkable advancements in solid-state NMR for obtaining molecular-level structural and dynamic information.
  • Detailed explanation of spectral effects arising from quadrupolar interactions under static and magic angle spinning (MAS) conditions.
  • Comparative analysis of advanced high-resolution techniques for half-integer quadrupolar nuclei, highlighting their strengths and applications.
  • Successful application of these methods for probing nuclear spin interactions.

Conclusions:

  • Solid-state NMR of quadrupolar nuclei has evolved into a powerful tool for molecular structure and dynamics determination.
  • The reviewed techniques offer diverse strategies for overcoming spectral complexities and achieving high resolution.
  • Future research directions likely involve further refinement of these methods and their application to increasingly complex systems.