Related Experiment Video
Updated: Aug 19, 2026

A 3D System for Culturing Human Articular Chondrocytes in Synovial Fluid
Published on: January 31, 2012
[The collagenolytic and general proteolytic activity in synovial fluid cells in rheumatoid arthritis]
Abstract:
The authors made a comparative study of collagenolytic (CA) and neutral caseinolytic activity (NCA) in the cells of the synovial fluid (CSF) depending on the peculiarities of the course of rheumatoid process and also on the duration of the disease prior to and after treatment of rheumatoid arthritis (RA). It has been shown that proteinase is one of the factors of RA pathogenesis. The level of enzymes directly depended on the activity of synovitis. The data obtained show that with a rapidly progressing RA and also with the III degree of the disease activity, CA in CSF were twice as high as those observed with a slowly progressing RA and also with the I-II degree of RA activity. The treatment conducted promoted a rise in CA, NCA in CSF. The possible mechanism of these processes is being discussed.
Related Concept Videos
The JAK-STAT Signaling Pathway
Glycosaminoglycans
GAGS are found in the extracellular matrix of vertebrates, invertebrates, and bacteria. Due to their polar nature they attract water, and serve as excellent lubricants or shock absorbers in an animal body.
Hyaluronic...
Fibril-associated Collagen
For example, the type II collagen fibrils in cartilage have covalently bound type IX fibril-associated collagens at regular intervals. Other types of fibril-associated collagens are...
Role of Matrix Metalloproteases in Degradation of ECM
A...
Inflammatory Response
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
T Cell Types and Functions
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...

