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Updated: Jun 1, 2026

Antimicrobial Characterization of Advanced Materials for Bioengineering Applications

Antimicrobial Characterization of Advanced Materials for Bioengineering Applications

Published on: August 4, 2018

Polymeric antimicrobial N-halamine epoxides.

Hasan B Kocer¹, Idris Cerkez, S D Worley

¹Department of Chemistry and Biochemistry, Auburn University, Auburn, Alabama 36849, USA.

ACS Applied Materials & Interfaces

|June 11, 2011

Summary

This summary is machine-generated.

A novel N-halamine copolymer coating for cellulose fibers was developed. This antimicrobial coating effectively inactivates bacteria and shows stability against washing and UV light.

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High-throughput Identification of Bacteria Repellent Polymers for Medical Devices

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Published on: November 5, 2016

Area of Science:

Materials Science
Polymer Chemistry
Antimicrobial Technology

Background:

N-halamine compounds are known for their potent antimicrobial properties.
Developing stable and effective antimicrobial coatings for textiles is crucial for hygiene applications.
Cellulose-based materials offer a sustainable platform for functional coatings.

Purpose of the Study:

To synthesize and characterize a new N-halamine copolymer.
To covalently bind the copolymer to cellulose fibers (cotton).
To evaluate the antimicrobial efficacy, hydrolytic stability, and UVA degradation stability of the functionalized material.

Main Methods:

Copolymerization of 3-chloro-2-hydroxypropylmethacrylate and glycidyl methacrylate.
Coating the copolymer onto cotton fibers followed by curing.
Treatment with potassium salt of 5,5-dimethylhydantoin to create the N-halamine structure.
Exposure to household bleach (sodium hypochlorite) to activate antimicrobial properties.
Testing inactivation of Staphylococcus aureus and Escherichia coli O157:H7.
Assessing stability through washing and UVA exposure.

Main Results:

The N-halamine copolymer coating was successfully prepared and characterized.
The functionalized cotton demonstrated rapid inactivation of S. aureus and E. coli O157:H7.
The antimicrobial coating exhibited significant stability against hydrolysis and UVA degradation.
The coating remained effective after washing cycles.

Conclusions:

A covalently bound N-halamine copolymer coating on cellulose fibers provides durable and effective antimicrobial activity.
This technology offers a promising approach for developing self-sanitizing textiles.
The material's stability suggests potential for long-term use in various applications.