European cystic fibrosis bone mineralisation guidelines
Isabelle Sermet-Gaudelus1, Maria Luisa Bianchi, Michèle Garabédian
1Pôle de Pediatric Multidisciplinaire, Hôpital Necker, Université René Descartes, 75015 Paris, France.
Summary
Cystic fibrosis patients often experience low bone density and fractures. This paper offers expert consensus on managing bone health in cystic fibrosis, covering assessment, prevention, and treatment strategies.
Area of Science:
- Bone biology and metabolic disorders
- Pulmonary medicine and genetics
- Clinical practice guidelines
Background:
- Cystic fibrosis (CF) is associated with significant risks of low bone mineral density (BMD) and fragility fractures.
- Understanding the epidemiology and pathophysiology of CF-related skeletal deficits is crucial for effective patient management.
- Existing knowledge gaps necessitate updated guidance for healthcare professionals.
Framework:
- Consensus statements developed using a modified Delphi methodology.
- Summarizes current knowledge on CF-related bone disease.
- Provides evidence-based recommendations for clinical practice.
Implementation:
- Guidance on the assessment of bone health in CF patients.
- Strategies for the prevention of skeletal complications.
- Recommendations for the treatment of low BMD and fractures in CF.
Implications:
- Aims to improve bone health outcomes for individuals with cystic fibrosis.
- Facilitates standardized care and management of skeletal issues in CF.
- Supports clinical decision-making for healthcare providers managing CF patients.
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