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Glycerylphosphocholine phosphocholine phosphodiesterase activity is reduced in multiple sclerosis plaques
L Janzen1, W W Tourtellotte, J N Kanfer
1University of Manitoba, Winnipeg, Canada.
Experimental Neurology
|August 1, 1990
Abstract:
Glycerylphosphorylcholine (GPC) phosphocholine phosphodiesterase activity (EC 3.1.4.38) is significantly reduced in multiple sclerosis plaques compared to adjacent tissue with a P less than 0.01 based upon the Student-Newman-Keuls or Tukey test. This finding is in accord with the proposal that this particular form of the enzyme is myelin-specific. Similar activities for GPC phosphocholine phosphodiesterase were obtained with samples from various regions of the same individual brain.