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Updated: Jun 1, 2026

A Step Beyond BRET: Fluorescence by Unbound Excitation from Luminescence (FUEL)

A Step Beyond BRET: Fluorescence by Unbound Excitation from Luminescence (FUEL)

Published on: May 23, 2014

Mechanoluminescent light source for a fluorescent probe molecule.

Nao Terasaki¹, Hongwu Zhang, Hiroshi Yamada

¹National Institute of Advanced Industrial Science and Technology, Measurement Sensing Technology Research Center, 807-1 Shuku-machi, Tosu, Saga 841-0052, Japan. nao-terasaki@aist.go.jp

Chemical Communications (Cambridge, England)

|June 11, 2011

Summary

Mechanoluminescent (ML) materials can now act as light sources. Smart size control and mechanical stimulation enable in situ bio-imaging and phototherapy applications within the human body.

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Area of Science:

Materials Science
Biomedical Engineering
Optics

Background:

Mechanoluminescence (ML) is a phenomenon where materials emit light upon mechanical stimulation.
Existing light sources for in vivo applications face limitations in penetration, biocompatibility, or invasiveness.

Purpose of the Study:

To demonstrate the novel application of mechanoluminescent materials as an in situ light source.
To explore the potential of ML materials for biomedical applications like bio-imaging and phototherapy.

Main Methods:

Utilizing mechanoluminescent particles with precisely controlled sizes.
Applying non-destructive mechanical stimulation to induce light emission.
Evaluating the feasibility of ML materials for in vivo light generation.

Main Results:

Successfully demonstrated ML materials as a functional light source for the first time.
Showcased the ability to control light emission through smart size control and mechanical stimulation.
Indicated ML particles as promising candidates for internal light generation in biological systems.

Conclusions:

Mechanoluminescent materials represent an innovative, self-contained light source.
ML particles offer a promising platform for future in situ bio-imaging and phototherapy modalities.
The technology holds potential for minimally invasive or non-invasive biomedical optical applications.