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Related Experiment Video

Updated: Jun 1, 2026

Detrusor Underactivity Model in Rats by Conus Medullaris Transection

Detrusor Underactivity Model in Rats by Conus Medullaris Transection

Published on: August 28, 2020

Detrusor underactivity: a plea for new approaches to a common bladder dysfunction.

G A van Koeveringe¹, B Vahabi, K E Andersson

¹Department of Urology and Pelvic care Center Maastricht, Maastricht University Medical Centre, Maastricht, The Netherlands. g.van.koeveringe@mumc.nl

Neurourology and Urodynamics

|June 11, 2011

Summary

Detrusor underactivity (DU) is a bladder contraction issue affecting bladder emptying. Current knowledge on DU pathophysiology, epidemiology, and treatment is limited, necessitating further research into its causes and management.

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A Decentralized (Ex Vivo) Murine Bladder Model with the Detrusor Muscle Removed for Direct Access to the Suburothelium during Bladder Filling

A Decentralized (Ex Vivo) Murine Bladder Model with the Detrusor Muscle Removed for Direct Access to the Suburothelium during Bladder Filling

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Last Updated: Jun 1, 2026

Detrusor Underactivity Model in Rats by Conus Medullaris Transection

Detrusor Underactivity Model in Rats by Conus Medullaris Transection

Published on: August 28, 2020

A Decentralized (Ex Vivo) Murine Bladder Model with the Detrusor Muscle Removed for Direct Access to the Suburothelium during Bladder Filling

A Decentralized (Ex Vivo) Murine Bladder Model with the Detrusor Muscle Removed for Direct Access to the Suburothelium during Bladder Filling

Published on: November 28, 2019

Area of Science:

Urology
Continence Research
Lower Urinary Tract Symptoms

Background:

Detrusor underactivity (DU) is characterized by reduced bladder contractility, leading to incomplete emptying.
Despite its impact on bladder function, DU has received limited research attention.

Purpose of the Study:

To summarize the 2010 International Continence Society-Research Society (ICI-RS) meeting discussions on detrusor underactivity.
To outline future research directions for understanding and managing DU.

Main Methods:

A think tank discussion format was employed.
The summary of discussions was presented and finalized by ICI-RS participants.

Main Results:

Understanding of DU pathophysiology, epidemiology, assessment, and treatment remains basic.
No consensus exists on quantifying DU using pressure-flow analysis.
Aging and other factors contribute to reduced detrusor contractility, with limited effective treatments available.

Conclusions:

Future research should focus on novel animal models and non-invasive tests for DU pathogenesis.
Optimizing evaluation algorithms and conducting epidemiological studies are crucial for developing effective DU treatments.