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Shifting Zebrafish Lethal Skeletal Mutant Penetrance by Progeny Testing
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[Unraveling the ichthyosis types].

T Hermanns-Lê1, M A Reginster, P Quatresooz

  • 1CHU du Sart Tilman, Service de Dermatopathologie, Université de Franche-Comté, Hôpital Saint-Jacques, Besançon, France.

Revue Medicale De Liege
|June 14, 2011
PubMed
Summary
This summary is machine-generated.

Ichthyoses are genetic skin disorders affecting keratinization. This review covers the most common types of hereditary ichthyoses, detailing their varied clinical and genetic features.

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Published on: September 1, 2017

Area of Science:

  • Dermatology
  • Genetics
  • Molecular Biology

Context:

  • Ichthyoses represent a group of keratinization disorders.
  • These conditions exhibit significant clinical and histopathological heterogeneity.
  • Both hereditary and acquired forms of ichthyosis exist.

Purpose:

  • To review the most frequent types of hereditary ichthyoses.
  • To highlight the heterogeneity in clinical presentation and histopathology.
  • To discuss the underlying molecular and genetic alterations.

Summary:

  • Ichthyoses are a diverse group of genetic skin diseases.
  • They are characterized by abnormal keratinization.
  • This review focuses on common hereditary forms, emphasizing their varied presentations and genetic bases.

Impact:

  • Provides a consolidated overview of common hereditary ichthyoses.
  • Aids in understanding the complexity of keratinization disorders.
  • Facilitates differential diagnosis and genetic counseling for ichthyosis patients.