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Related Concept Videos

Loss of Tumor Suppressor Gene Functions01:12

Loss of Tumor Suppressor Gene Functions

Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
When the tumor suppressor genes develop mutations or are lost, cells start growing out of control, leading to cancer. However, a single functional copy of the tumor suppressor gene is enough for the cells to maintain their normal functions and cell...
Loss of Tumor Suppressor Gene Functions01:12

Loss of Tumor Suppressor Gene Functions

Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
When the tumor suppressor genes develop mutations or are lost, cells start growing out of control, leading to cancer. However, a single functional copy of the tumor suppressor gene is enough for the cells to maintain their normal functions and cell...
Cancer-Critical Genes I: Proto-oncogenes01:33

Cancer-Critical Genes I: Proto-oncogenes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
Cancer-Critical Genes I: Proto-oncogenes01:33

Cancer-Critical Genes I: Proto-oncogenes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
Cancer-Critical Genes II: Tumor Suppressor Genes01:05

Cancer-Critical Genes II: Tumor Suppressor Genes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
Cancer-Critical Genes II: Tumor Suppressor Genes01:05

Cancer-Critical Genes II: Tumor Suppressor Genes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...

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Oncogene Expression Analysis with Alterations in pH in a Pancreatic Ductal Cell Line
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GRIM-19 function in cancer development.

Severina Moreira1, Marcelo Correia, Paula Soares

  • 1Institute of Molecular Pathology and Immunology of University of Porto (IPATIMUP), Rua Dr. Roberto Frias, s/n, 4200-465 Porto, Portugal.

Mitochondrion
|June 14, 2011
PubMed
Summary
This summary is machine-generated.

The GRIM-19 gene is a newly discovered tumor suppressor. Mutations and loss of GRIM-19 protein expression are linked to various cancers, highlighting its role in carcinogenesis.

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Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Cancer development involves genetic alterations in tumor suppressor genes.
  • Tumor suppressor genes function recessively, requiring loss of function in both alleles.
  • GRIM-19 is a recently identified tumor suppressor gene.

Purpose of the Study:

  • To review the current understanding of the GRIM-19 gene's function in cancer development.
  • To detail the role of GRIM-19 in carcinogenesis.
  • To explore the implications of GRIM-19 mutations and expression loss in various tumor types.

Main Methods:

  • Literature review of existing research on GRIM-19.
  • Analysis of studies reporting GRIM-19 gene mutations.
  • Examination of data on GRIM-19 protein expression levels in tumors.

Main Results:

  • GRIM-19 mutations and reduced protein expression are found in multiple cancer types.
  • These alterations are consistent with GRIM-19 acting as a tumor suppressor.
  • The findings suggest a significant role for GRIM-19 in preventing tumor formation.

Conclusions:

  • GRIM-19 is a crucial tumor suppressor gene involved in carcinogenesis.
  • Loss of GRIM-19 function contributes to cancer development.
  • Further research into GRIM-19 mechanisms is warranted for therapeutic strategies.