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Published on: November 9, 2014
How much do resin-based dental materials release? A meta-analytical approach.
K L Van Landuyt1, Tim Nawrot, B Geebelen
1Leuven BIOMAT Research Cluster, Department of Conservative Dentistry, School of Dentistry, Oral Pathology and Maxillo-Facial Surgery, Catholic University of Leuven, Kapucijnenvoer 7, B-3000 Leuven, Belgium. kirsten.vanlanduyt@med.kuleuven.be
Summary
Dental resin materials release monomers and additives, with higher elution in organic environments. Further standardized research is needed to quantify patient exposure to these dental eluates.
Area of Science:
- Dental Materials Science
- Analytical Chemistry
- Toxicology
Background:
- Resin-based dental materials can release components due to incomplete polymerization and degradation.
- Concerns about potential toxicity necessitate precise quantification of released eluates.
- Varied analytical methods and result presentations hinder understanding of patient exposure levels.
Purpose of the Study:
- To review literature on short- and long-term component release from resin-based dental materials.
- To determine the magnitude of component leaching in the oral cavity.
- To address the lack of standardized analytical research in this field.
Main Methods:
- Meta-analysis of 22 selected studies from an initial set of 71.
- Calculation of meta-analytical means for evaluated eluates, despite methodological variability.
- Estimation of standard composite restoration size using 3D graphical software to correlate eluate release with restoration volume.
Main Results:
- Monomer release was frequently studied, while additive release (initiators, inhibitors, stabilizers) was seldom investigated.
- Significantly higher component release was observed in organic media compared to water-based media.
- Resin-based materials may contribute significantly to ingested bisphenol A and release substantial amounts of monomers (HEMA, TEGDMA, BisGMA, UDMA) and potentially higher amounts of additives.
Conclusions:
- A clear need exists for more accurate and standardized analytical research on long-term release from resin-based materials.
- Proposed guidelines for standardization are crucial for future research.
- Accurate quantification is essential for assessing patient exposure and potential risks.
