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An Introduction to Parasitic Wasps of Drosophila and the Antiparasite Immune Response
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The carbohydrate ligands on the host embryo mediate intercellular migration of the parasitic wasp embryo

Azusa Takahashi-Nakaguchi1, Tsuyoshi Hiraoka, Kikuo Iwabuchi

  • 1Tokyo University of Agriculture and Technology, Tokyo, Japan.

FEBS Letters
|June 14, 2011
PubMed

Invasive stage embryos of the parasitic wasp Copidosoma floridanum transmigrate through the epithelium of phylogenetically distant host embryos in a manner that is similar to mammalian leukocyte infiltration. Host embryonic cells appear to recognize the invading wasp embryo by components on the cell surface. We developed an in vitro wasp entry inhibition assay and found that C-type lectins of the wasp embryo bound to N-linked carbohydrate chains with fucose residues on the surface of host embryo. This is the first report showing a receptor-ligand interaction between heterologous multicellular organisms.

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