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Published on: June 15, 2019
[Clonal eosinophilia revealed by recurrent Staphylococcus aureus infection]
F Vandenbos1, M Figueredo, M-C Dumon-Gubeno
1Centre de réhabilitation cardio-respiratoire « La Maison du Mineur », Vence, France. f.vandenbos@maisondumineur.com
Revue De Pneumologie Clinique
|June 14, 2011
Summary
A 47-year-old male with recurring Staphylococcus aureus infections was diagnosed with clonal eosinophilia due to the FIP1L1-PDGFRA fusion gene. Imatinib mesylate effectively treated both the eosinophilia and the infection.
Area of Science:
- Hematology
- Oncology
- Molecular Biology
Background:
- Acquired eosinophilia is classified into secondary, clonal, and idiopathic categories.
- Clonal eosinophilia is characterized by specific molecular or genetic markers indicating myeloid malignancy.
Observation:
- A 47-year-old male presented with recurrent Staphylococcus aureus infections.
- Hypereosinophilia was detected, prompting molecular analysis.
- The FIP1L1-PDGFRA fusion gene was identified.
Findings:
- The FIP1L1-PDGFRA fusion gene confirmed clonal eosinophilia.
- Treatment with imatinib mesylate achieved hematological remission.
- Imatinib mesylate also controlled the patient's infection and aided wound healing.
Implications:
- This case highlights an unusual infectious presentation of clonal eosinophilia.
- Imatinib mesylate demonstrated efficacy in managing both clonal eosinophilia and associated infections.
- Targeted therapy can be effective even in complex clinical scenarios involving hematological disorders and infections.
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