Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Secondary Spinal Cord Injury llI: Pathophysiology01:25

Secondary Spinal Cord Injury llI: Pathophysiology

Early Ischemia and Ionic ImbalanceWithin minutes of spinal cord injury, a secondary cascade begins, progressing over hours to weeks. Vascular damage reduces blood flow, causing ischemia and mitochondrial dysfunction. ATP depletion leads to ion pump failure, membrane depolarization, sodium influx, potassium efflux, and water accumulation, resulting in cellular swelling. Increased intracellular calcium further disrupts mitochondria and accelerates cellular injury.Excitotoxicity and Neuronal...
Alzheimer Disease ll: Pathophysiology01:23

Alzheimer Disease ll: Pathophysiology

Alzheimer disease involves structural changes in the brain that begin long before symptoms appear. The most distinctive features are extracellular neuritic plaques and intracellular neurofibrillary tangles.Neuritic plaques form in the cerebral cortex and around blood vessels. These plaques contain a dense core of beta-amyloid (Aβ)—a toxic protein fragment that clumps outside neurons. The core is surrounded by damaged neuronal extensions, as well as reactive astrocytes and microglia. Abnormal...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Corrigendum to "Spontaneous narrative production in focal neurodegenerative disease" [Neuropsychologia 97 (2015) 158-171].

Neuropsychologia·2018
Same author

Murine knockin model for progranulin-deficient frontotemporal dementia with nonsense-mediated mRNA decay.

Proceedings of the National Academy of Sciences of the United States of America·2018
Same author

Frontotemporal dementia.

Handbook of clinical neurology·2018
Same author

Increased subjective experience of non-target emotions in patients with frontotemporal dementia and Alzheimer's disease.

Current opinion in behavioral sciences·2018
Same author

Early vs late age at onset frontotemporal dementia and frontotemporal lobar degeneration.

Neurology·2018
Same author

The Longitudinal Trajectory of Default Mode Network Connectivity in Healthy Older Adults Varies As a Function of Age and Is Associated with Changes in Episodic Memory and Processing Speed.

The Journal of neuroscience : the official journal of the Society for Neuroscience·2018

Related Experiment Video

Updated: Jun 1, 2026

Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases
09:33

Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases

Published on: July 28, 2013

White matter damage in primary progressive aphasias: a diffusion tensor tractography study.

Sebastiano Galantucci1, Maria Carmela Tartaglia, Stephen M Wilson

  • 1Memory and Ageing Centre, Department of Neurology, University of California, San Francisco, San Francisco, CA 94143-1207, USA.

Brain : a Journal of Neurology
|June 14, 2011
PubMed
Summary

This study reveals distinct white matter damage patterns in primary progressive aphasia (PPA) variants using diffusion tensor imaging. Non-fluent PPA showed dorsal pathway changes, semantic PPA affected ventral and dorsal pathways, and logopenic PPA had minimal white matter alterations.

More Related Videos

Measuring Connectivity in the Primary Visual Pathway in Human Albinism Using Diffusion Tensor Imaging and Tractography
13:26

Measuring Connectivity in the Primary Visual Pathway in Human Albinism Using Diffusion Tensor Imaging and Tractography

Published on: August 11, 2016

DTI of the Visual Pathway - White Matter Tracts and Cerebral Lesions
10:05

DTI of the Visual Pathway - White Matter Tracts and Cerebral Lesions

Published on: August 26, 2014

Related Experiment Videos

Last Updated: Jun 1, 2026

Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases
09:33

Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases

Published on: July 28, 2013

Measuring Connectivity in the Primary Visual Pathway in Human Albinism Using Diffusion Tensor Imaging and Tractography
13:26

Measuring Connectivity in the Primary Visual Pathway in Human Albinism Using Diffusion Tensor Imaging and Tractography

Published on: August 11, 2016

DTI of the Visual Pathway - White Matter Tracts and Cerebral Lesions
10:05

DTI of the Visual Pathway - White Matter Tracts and Cerebral Lesions

Published on: August 26, 2014

Area of Science:

  • Neuroimaging
  • Neurology
  • Neuroscience

Background:

  • Primary progressive aphasia (PPA) presents with three main phenotypes: non-fluent/agrammatic, semantic, and logopenic.
  • Previous research primarily focused on grey matter atrophy, with network-level white matter dysfunction hypothesized but less studied.
  • Understanding white matter integrity is crucial for diagnosing and differentiating PPA subtypes.

Purpose of the Study:

  • To investigate and characterize white matter tract integrity across the three main PPA variants.
  • To compare diffusion tensor imaging (DTI) metrics in white matter tracts among PPA subtypes and controls.

Main Methods:

  • Diffusion tensor imaging (DTI) was employed on 48 participants (9 non-fluent, 9 semantic, 9 logopenic PPA, and 21 controls).
  • Probabilistic tractography was used to analyze the inferior longitudinal fasciculi (ventral pathway) and superior longitudinal fasciculus (dorsal pathway).
  • Fractional anisotropy (FA) and diffusivity metrics (axial, radial, mean) were compared across diagnostic groups for specific white matter tracts.

Main Results:

  • Non-fluent PPA showed significant white matter changes in dorsal pathways.
  • Semantic variant PPA exhibited widespread alterations in both ventral and dorsal pathways.
  • Logopenic PPA displayed the least white matter damage, primarily affecting diffusivity in the temporoparietal dorsal pathway component.

Conclusions:

  • Distinct patterns of white matter alterations characterize each PPA variant, supporting the use of DTI in differential diagnosis.
  • Analysis of specific language tracts and comprehensive DTI metrics are essential for accurately assessing PPA.
  • DTI shows promise as a valuable tool in the multimodal diagnostic evaluation of primary progressive aphasia.