Related Experiment Video
Updated: Jun 1, 2026

Rapid Formation and Testing of Self-expanding NiTi Frames with a Small Form Factor Suitable for Minimally Invasive Implants
Published on: March 7, 2025
Cytotoxicity of Metal Ions Released from Nitinol Alloys on Endothelial Cells
1Department of Materials Science and Engineering, Penn State University, University Park, PA.
Abstract:
Most implantable medical devices are expected to function in the body over an extended period of time. Therefore, immersion tests under simulated conditions can be useful for assessing the amount of metal ions released in situ. In this investigation, dissolved ions from as-received binary and ternary Nitinol alloys in cell culture media were periodically measured under static and dynamic conditions. Endothelial cells were grown in aliquots of culture media obtained and the effect of dissolved ions on cell proliferation and viability of endothelial cells (HUVEC) was studied by cytotoxicity assays. The concentration of metal ions in the media was measured by inductively coupled plasma mass spectrometry.
Related Concept Videos
Myocarditis I: Introduction
Bioactivation and Tissue Toxicity
Cellular Injury IV: Necrosis

