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Van der Waals Interactions

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Atoms and molecules interact with each other through intermolecular forces. These electrostatic forces arise from attractive or repulsive interactions between particles with permanent, partial, or temporary charges. The intermolecular forces between neutral atoms and molecules are ion–dipole, dipole–dipole, and dispersion forces, collectively known as van der Waals forces.

Valence Bond Theory

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Coordination compounds and complexes exhibit different colors, geometries, and magnetic behavior, depending on the metal atom/ion and ligands from which they are composed. In an attempt to explain the bonding and structure of coordination complexes, Linus Pauling proposed the valence bond theory, or VBT, using the concepts of hybridization and the overlapping of the atomic orbitals. According to VBT, the central metal atom or ion (Lewis acid) hybridizes to provide empty orbitals of suitable...

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The hemoglobin in the blood, the chlorophyll in green plants, vitamin B-12, and the catalyst used in the manufacture of polyethylene all contain coordination compounds. Ions of the metals, especially the transition metals, are likely to form complexes.
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Anticancer Metal Complexes: Synthesis and Cytotoxicity Evaluation by the MTT Assay

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Antidiabetic vanadium compound and membrane interfaces: interface-facilitated metal complex hydrolysis.

Debbie C Crans¹, Samantha Schoeberl, Ernestas Gaidamauskas

¹Department of Chemistry, Colorado State University, Fort Collins, CO 80523-1872, USA. crans@lamar.colostate.edu

Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry

|June 14, 2011

Summary

This study investigated how antidiabetic drug BMOV metabolites interact with lipid models. Findings suggest a novel mechanism for signal transduction involving membrane penetration and interaction with lipid head groups.

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Atomic Layer Deposition of Vanadium Dioxide and a Temperature-dependent Optical Model

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Published on: May 23, 2018

Area of Science:

Biochemistry
Pharmacology
Materials Science

Background:

Vanadium-based drugs, like bis(maltolato)oxovanadium(IV) (BMOV), are used for diabetes treatment.
Understanding their interaction with biological membranes is crucial for elucidating their mechanism of action.

Purpose of the Study:

To investigate the interaction of BMOV metabolites with lipid interface model systems.
To propose a novel mechanism for membrane-receptor-mediated signal transduction initiated by these compounds.

Main Methods:

Spectroscopic studies (1H and 51V NMR) were employed to probe interactions.
Model systems using cetyltrimethylammonium bromide (CTAB) micelles and reverse micelles were utilized.
Dynamic light scattering and conductivity measurements confirmed the model system's nature.

Main Results:

BMOV metabolites and the maltol ligand strongly interacted with lipid interfaces, particularly in micellar form.
Both the complex and ligand penetrated the lipid interface, localizing near the charged head group.
Lipid interfaces influenced the stability of the BMOV complex, suggesting potential ligand exchange.

Conclusions:

The findings support a novel mechanism for BMOV's action involving lipid interface interactions.
Ligand exchange at the lipid interface may be critical for BMOV's therapeutic effects.
These results align with in vivo observations of BMOV membrane penetration and glucose transporter translocation.