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Related Experiment Video

Updated: Jun 1, 2026

A Microfluidic Flow Chamber Model for Platelet Transfusion and Hemostasis Measures Platelet Deposition and Fibrin Formation in Real-time
09:38

A Microfluidic Flow Chamber Model for Platelet Transfusion and Hemostasis Measures Platelet Deposition and Fibrin Formation in Real-time

Published on: February 14, 2017

Methods for testing platelet function for transfusion medicine.

S Panzer1, P Jilma

  • 1Department for Blood Group Serology and Transfusion Medicine, Medical University Vienna, Vienna, Austria. simon.panzer@meduniwien.ac.at

Vox Sanguinis
|June 15, 2011
PubMed
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Monitoring platelet function in platelet concentrates (PC) currently relies on indirect measures. This review evaluates various methods for assessing platelet function in donors, PCs, and post-transfusion.

Area of Science:

  • Transfusion Medicine
  • Hematology
  • Biotechnology

Background:

  • Current methods for monitoring platelet function in platelet concentrates (PC) are indirect.
  • Advancements in PC production technology necessitate updated functional assessment methods.

Purpose of the Study:

  • To provide an overview of commercialized methods for determining platelet function.
  • To evaluate these methods for screening donors, assessing PC hemostatic properties, and post-transfusion monitoring.

Main Methods:

  • Review of no/low shear methods: light-transmission aggregometry, flow cytometry, multiple electrode aggregometry, thrombelastography, dynamic light scattering.
  • Review of high shear methods: Platelet Function Analyzer-100, cone and plate analyzer.
  • Focus on methods reported in the last 10 years.

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Microfluidics in Assessing Platelet Function
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Microfluidics in Assessing Platelet Function

Published on: November 8, 2024

Routine Screening Method for Microparticles in Platelet Transfusions
09:49

Routine Screening Method for Microparticles in Platelet Transfusions

Published on: January 31, 2018

Related Experiment Videos

Last Updated: Jun 1, 2026

A Microfluidic Flow Chamber Model for Platelet Transfusion and Hemostasis Measures Platelet Deposition and Fibrin Formation in Real-time
09:38

A Microfluidic Flow Chamber Model for Platelet Transfusion and Hemostasis Measures Platelet Deposition and Fibrin Formation in Real-time

Published on: February 14, 2017

Microfluidics in Assessing Platelet Function
06:47

Microfluidics in Assessing Platelet Function

Published on: November 8, 2024

Routine Screening Method for Microparticles in Platelet Transfusions
09:49

Routine Screening Method for Microparticles in Platelet Transfusions

Published on: January 31, 2018

Main Results:

  • No/low shear methods assess specific platelet functions.
  • High shear methods provide a general analysis of platelet hemostatic competence.
  • No strong correlation found between in vitro data and clinical outcomes.

Conclusions:

  • Different methods offer distinct insights into platelet function.
  • Clinical relevance of current in vitro platelet function tests remains uncertain.
  • Further research is needed to bridge the gap between laboratory findings and clinical efficacy.