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Related Experiment Videos

Calcium and cell cycle control.

M Whitaker1, R Patel

  • 1Department of Physiology, University College London, UK.

Development (Cambridge, England)
|April 1, 1990
PubMed
Summary
This summary is machine-generated.

Early sea urchin embryos utilize intracellular calcium transients to regulate key cell cycle control points. These calcium signals control cell cycle proteins, similar to yeast and mammalian systems.

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Area of Science:

  • Developmental Biology
  • Cell Cycle Regulation
  • Calcium Signaling

Background:

  • The early sea urchin embryo exhibits a fundamental cell division cycle.
  • This cycle shares conserved control points (START, mitosis ENTRY, mitosis EXIT) with yeast and mammalian cell cycles.
  • Understanding these conserved mechanisms provides insights into fundamental biological processes.

Purpose of the Study:

  • To investigate the role of intracellular free calcium (Cai) transients in regulating the sea urchin embryo cell cycle.
  • To compare calcium-mediated cell cycle regulation in sea urchins with other species, including mammalian cells.

Main Methods:

  • Observation of transient increases in intracellular free calcium (Cai) at critical cell cycle stages.
  • Analysis of translational and post-translational regulation of cell cycle proteins pp34 and cyclin by Cai transients.

Related Experiment Videos

  • Comparative analysis of calcium's role in cell cycle progression across different species.

    • Main Results:

    • Progression through START, mitosis ENTRY, and mitosis EXIT is triggered by Cai transients in sea urchin embryos.
    • START Cai transient induces pp34 phosphorylation and cyclin synthesis.
    • Mitosis ENTRY Cai transient triggers cyclin phosphorylation, while mitosis EXIT Cai transient causes phosphorylated cyclin destruction.

    Conclusions:

    • Intracellular calcium transients are crucial regulators of the sea urchin embryo cell cycle.
    • Sea urchin cell cycle control mechanisms involving calcium show significant parallels with yeast and mammalian systems.
    • Calcium signaling provides a conserved mechanism for regulating fundamental cell cycle events.