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Analysis of the correlation between non-high density lipoprotein cholesterol and coronary heart disease in elderly
Dazhi Ke1, Qingwei Chen, Qing Wu
1Department of Geriatrics Cardiology, the Second Affiliated Hospital of Chongqing Medical University, PR China.
Insights
Serum non-high density lipoprotein cholesterol (non-HDL-C) is linked to coronary heart disease (CHD) risk. Higher non-HDL-C levels correlate with increased severity of coronary artery lesions in elderly patients.
Area of Science:
- Cardiology
- Geriatrics
- Lipid Metabolism
Background:
- Serum cholesterol is a known risk factor for coronary heart disease (CHD) in the elderly.
- Non-high density lipoprotein cholesterol (non-HDL-C) is increasingly recognized as a key indicator of cardiovascular risk.
Purpose of the Study:
- To investigate the association between non-HDL-C levels and the presence and severity of CHD.
- To analyze the correlation between non-HDL-C and coronary artery lesions in an aged population.
Main Methods:
- Retrospective analysis of 1,272 elderly patients (>65 years) undergoing coronary angiography.
- Patients categorized into control and CHD groups, with CHD patients further stratified by lesion number and Gensini score.
- Serum lipid profiles assayed to determine non-HDL-C levels for comparative and correlational analyses.
Main Results:
- Significantly higher non-HDL-C levels were observed in the CHD group compared to the control group (p < 0.01).
- Non-HDL-C levels increased progressively with the number of affected coronary artery branches and the severity of stenosis (Gensini score).
- Significant positive correlations found between non-HDL-C and both the area and severity of coronary lesions (r = 0.147, p < 0.01; r = 0.152, p < 0.01).
Conclusions:
- Serum non-HDL-C is closely associated with the development of CHD in the elderly.
- Elevated non-HDL-C levels are indicative of more severe coronary artery lesions.
Objective:
In the aged population, serum cholesterol is directly correlated with coronary heart disease (CHD) risk. We aimed to investigate the correlation between non-high density lipoprotein cholesterol (non-HDL-C) level and CHD and coronary lesions in an aged population.
Methods:
1,272 cases of old patients who were more than 65 years old and accepted for coronary angiography were analyzed retrospectively. Based on the result of coronary angiography, the patients were divided into control group and CHD group. Further, 767 CHD patients were divided into subgroups according to the number of branches with pathological changes and Gensini score. Serum TC, HDL-C, LDL-C and TG were assayed to measure the level of non-HDL-C. The differences in non-HDL-C among groups were compared, and the correlation between non-HDL-C and coronary artery disease degree was also analyzed.
Results:
The non-HDL-C level in the CHD group was significantly higher than that in the control group (p < 0.01). Further, the serum non-HDL-C showed an increasing tendency accompanied by the increase in branches with lesions. Compared with patients with single or double coronary artery branches lesions, the non-HDL-C in those with multiple lesions in branches was significantly increased (p < 0.01, p < 0.05). With the aggravation of coronary artery stenosis, the serum non-HDL-C level was gradually increased. The most significant increase was observed in the group with Gensini score of more than 40. There was a significant difference between Gensini score > 40 group and Gensini score of 20-40 group and Gensini score < 20 group, respectively (p < 0.05, p < 0.01). Meanwhile, there were significant positive correlations between the serum non-HDL-C level and coronary lesions area and severity (r = 0.147, p < 0.01; r = 0.152, p < 0.01).
Conclusion:
In conclusion, serum non-HDL-C was closely associated with development of CHD and coronary artery lesions severity.
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