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Establishment of a Clinic-based Biorepository
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Published on: May 29, 2017

p63 expression in adamantinoma.

Brendan C Dickson1, Yair Gortzak, Robert S Bell

  • 1Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada. bdickson@mtsinai.on.ca

Virchows Archiv : an International Journal of Pathology
|June 16, 2011
PubMed
Summary

Adamantinoma, a rare bone tumor, shares features with osteofibrous dysplasia. Researchers found p63 expression in both, suggesting a link and aiding in differentiating adamantinoma from metastatic carcinoma.

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Area of Science:

  • Oncology
  • Pathology
  • Genetics

Background:

  • Adamantinoma is a rare primary bone neoplasm with epithelial differentiation.
  • It often presents with a fibrous component, showing overlap with osteofibrous dysplasia.
  • A potential relationship between these two bone lesions has been suggested.

Purpose of the Study:

  • To characterize adamantinoma and osteofibrous dysplasia.
  • To compare p63 and keratin expression in these lesions.
  • To investigate the relationship between adamantinoma and osteofibrous dysplasia.

Main Methods:

  • Retrospective review of institutional archives.
  • Histomorphologic and immunohistochemical analysis (p63, keratin).
  • Comparison of expression patterns in adamantinoma, osteofibrous dysplasia, and fibrous dysplasia controls.

Main Results:

  • Nine adamantinomas (6 classical, 3 osteofibrous dysplasia-like) and 11 osteofibrous dysplasias were identified.
  • The epithelial component of adamantinoma stained positive for p63.
  • Rare p63-positive cells were found in 8/11 osteofibrous dysplasia cases, but not in fibrous dysplasia controls.

Conclusions:

  • The presence of p63 in osteofibrous dysplasia supports a relationship with adamantinoma.
  • p63 expression may aid in distinguishing adamantinoma from metastatic carcinoma.
  • Further research into the pathogenesis and differentiation of these bone lesions is warranted.