Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Tumor Progression02:07

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Tumor Progression02:07

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Bone Remodeling01:40

Bone Remodeling

Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
Bone Disorders01:29

Bone Disorders

Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Lumbar extradural extraosseous notochordal lesion resulting in radiculopathy: ecchordosis physaliphora versus chordoma. Illustrative case.

Journal of neurosurgery. Case lessons·2026
Same author

Ossifying Spindled and Epithelioid Tumor: A Novel Soft Tissue Tumor.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc·2025
Same author

Myopericytoma of the hand.

Skeletal radiology·2024
Same author

SARCP, a Clinical Next-Generation Sequencing Assay for the Detection of Gene Fusions in Sarcomas: A Description of the First 652 Cases.

The Journal of molecular diagnostics : JMD·2024
Same author

Evaluation of Long-Term Follow-Up in Ecchordosis Physaliphora versus Chordoma.

World neurosurgery·2023
Same author

Imaging of spinal chordoma and benign notochordal cell tumor (BNCT) with radiologic pathologic correlation.

Skeletal radiology·2022
Same journal

Update on the molecular pathology of the distinctive giant cell, fibro-osseous and bone forming lesions of the jaws.

Seminars in diagnostic pathology·2026
Same journal

Update on the molecular pathology and classification of odontogenic cysts and tumours.

Seminars in diagnostic pathology·2026
Same journal

MDM2 gene amplification in surgical pathology: biology, diagnostic utility, and clinical relevance in the modern era.

Seminars in diagnostic pathology·2026
Same journal

When three negatives equal a positive: Molecular updates of triple-negative breast carcinomas with favorable prognoses.

Seminars in diagnostic pathology·2026
Same journal

Old school, new insight: Revisiting histomorphology in the modern era of prostate cancer risk stratification.

Seminars in diagnostic pathology·2026
Same journal

Recent advances in genetic predisposition to primary testicular tumors.

Seminars in diagnostic pathology·2026
See all related articles

Related Experiment Video

Updated: Jun 1, 2026

Intra-iliac Artery Injection for Efficient and Selective Modeling of Microscopic Bone Metastasis
07:00

Intra-iliac Artery Injection for Efficient and Selective Modeling of Microscopic Bone Metastasis

Published on: September 26, 2016

Benign bone tumors--recent developments.

Roberto A Garcia1, Carrie Y Inwards, Krishnan K Unni

  • 1Department of Pathology, Mount Sinai School of Medicine, New York, New York 10029, USA. roberto.garcia@mountsinai.org

Seminars in Diagnostic Pathology
|June 17, 2011
PubMed
Summary
This summary is machine-generated.

Diagnosing benign bone tumors is challenging. Advances in molecular, cytogenetic, and osteoimmunology offer better understanding and diagnostic aids for these bone lesions.

More Related Videos

Murine Hind Limb Long Bone Dissection and Bone Marrow Isolation
07:17

Murine Hind Limb Long Bone Dissection and Bone Marrow Isolation

Published on: April 14, 2016

Modeling Primary Bone Tumors and Bone Metastasis with Solid Tumor Graft Implantation into Bone
06:53

Modeling Primary Bone Tumors and Bone Metastasis with Solid Tumor Graft Implantation into Bone

Published on: September 9, 2020

Related Experiment Videos

Last Updated: Jun 1, 2026

Intra-iliac Artery Injection for Efficient and Selective Modeling of Microscopic Bone Metastasis
07:00

Intra-iliac Artery Injection for Efficient and Selective Modeling of Microscopic Bone Metastasis

Published on: September 26, 2016

Murine Hind Limb Long Bone Dissection and Bone Marrow Isolation
07:17

Murine Hind Limb Long Bone Dissection and Bone Marrow Isolation

Published on: April 14, 2016

Modeling Primary Bone Tumors and Bone Metastasis with Solid Tumor Graft Implantation into Bone
06:53

Modeling Primary Bone Tumors and Bone Metastasis with Solid Tumor Graft Implantation into Bone

Published on: September 9, 2020

Area of Science:

  • Pathology
  • Oncology
  • Genetics

Background:

  • Benign bone tumors present diagnostic challenges for surgical pathologists.
  • Accurate diagnosis relies on integrating clinical, radiological, and pathological data.

Purpose of the Study:

  • To review recent advances in understanding benign bone tumors.
  • To highlight the role of molecular and cytogenetic findings in diagnosis.
  • To discuss the impact of osteoimmunology on pathophysiology and differential diagnosis.

Main Methods:

  • Review of recent scientific literature on benign bone tumors.
  • Analysis of molecular and cytogenetic findings.
  • Exploration of osteoimmunology in bone tumor research.

Main Results:

  • Significant advances in molecular and cytogenetic analysis aid in diagnosing challenging benign bone tumors.
  • Identification of clonal chromosomal aberrations and specific molecular events improves understanding.
  • Osteoimmunology provides insights into pathophysiology and differential diagnosis of overlapping bone lesions.

Conclusions:

  • Molecular and cytogenetic data are crucial for accurate diagnosis and differential diagnosis of benign bone tumors.
  • Understanding bone cell signaling pathways enhances knowledge of tumor pathophysiology.
  • Future research directions include prognostic and therapeutic applications of these molecular findings.