Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Psychotherapy01:28

Psychotherapy

Psychotherapy is a versatile, nonmedical approach aimed at helping individuals address emotional, behavioral, and interpersonal issues to enhance their overall well-being. It can involve one-on-one sessions, couples counseling, or small group discussions with a therapist. The therapeutic process includes various techniques such as open discussion, interpretation of thoughts and behaviors, active listening, positive reinforcement, and role modeling. Psychotherapy aims to support individuals in...
Humanistic Therapy01:24

Humanistic Therapy

Humanistic therapies emphasize personal growth, self-understanding, and the fulfillment of human potential. Rooted in the belief that individuals inherently strive toward self-actualization, these approaches encourage clients to explore their feelings and experiences in a supportive, nonjudgmental environment. Humanistic therapies differ from psychodynamic approaches by focusing on conscious experiences, present circumstances, and the potential for self-improvement rather than past conflicts...
Psychodynamic Therapy01:29

Psychodynamic Therapy

Psychodynamic therapies emphasize the exploration of unconscious processes and early childhood experiences as fundamental contributors to psychological difficulties. These therapies, deeply rooted in Freud's psychoanalytic theory, aim to uncover and resolve unconscious conflicts, granting individuals insights that promote emotional and behavioral healing. Contemporary psychodynamic approaches have evolved, integrating a broader range of influences and methodologies while still valuing the...
Couples Therapy01:26

Couples Therapy

Couples therapy is a therapeutic approach designed to help individuals in intimate relationships address conflicts, improve communication, and foster healthier dynamics. It is appropriate for couples at various stages, including those who are dating, married, or in long-term partnerships, and aims to support partners in navigating their unique relational challenges.
Core Principles and Techniques
Couples therapy often incorporates cognitive-behavioral principles to identify and modify negative...
Interpersonal Psychotherapy01:25

Interpersonal Psychotherapy

Interpersonal psychotherapy (IPT) is a structured, time-limited therapeutic approach initially developed to treat depression. It integrates key concepts from psychodynamic, humanistic, and cognitive-behavioral therapies, making it a uniquely eclectic framework. The therapy is rooted in the interpersonal theories of Adolph Meyer and Harry Stack Sullivan, as well as John Bowlby's attachment theory, and focuses on the interplay between interpersonal relationships and emotional well-being.
Elements Crucial for Effective Psychotherapy01:25

Elements Crucial for Effective Psychotherapy

Research has highlighted several critical factors that influence the effectiveness of psychotherapy, such as the therapeutic alliance, the therapist, and the client.
The Therapeutic Alliance
The therapeutic alliance refers to the relationship between the therapist and the client. The alliance strengthens when the therapist and the client engage in a nurturing, supportive, trusting, empathetic, and respectful relationship, improving therapeutic outcomes. Therapists must monitor this relationship...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Publisher Correction: Lysosomal storage diseases.

Nature reviews. Disease primers·2019
Same author

Author Correction: Lysosomal storage diseases.

Nature reviews. Disease primers·2018
Same author

Lysosomal storage diseases.

Nature reviews. Disease primers·2018
Same author

Delivery of an enzyme-IGFII fusion protein to the mouse brain is therapeutic for mucopolysaccharidosis type IIIB.

Proceedings of the National Academy of Sciences of the United States of America·2014
Same author

Unexpected observations--a tribute to Christian de Duve (1917-2013).

FASEB journal : official publication of the Federation of American Societies for Experimental Biology·2013
Same author

Defects in the medial entorhinal cortex and dentate gyrus in the mouse model of Sanfilippo syndrome type B.

PloS one·2011

Related Experiment Video

Updated: Jun 1, 2026

Using Visual and Narrative Methods to Achieve Fair Process in Clinical Care
14:32

Using Visual and Narrative Methods to Achieve Fair Process in Clinical Care

Published on: February 16, 2011

From serendipity to therapy.

Elizabeth F Neufeld1

  • 1Department of Biological Chemistry, David Geffen School of Medicine, University of California, Los Angeles, California 90095-1737, USA. neufeld@mednet.ucla.edu

Annual Review of Biochemistry
|June 17, 2011
PubMed
Summary

Accidental cell mixing revealed enzyme deficiencies in mucopolysaccharide storage diseases, paving the way for enzyme replacement therapy. Further research offers new therapeutic implications for Sanfilippo syndrome.

Area of Science:

  • Biochemistry
  • Cell Biology
  • Genetics

Background:

  • Postdoctoral research on plant polysaccharide biosynthesis unexpectedly shifted to mucopolysaccharide storage disorders at NIH.
  • Studies progressed from examining mucopolysaccharide turnover in cell cultures to developing patient therapies.

Discussion:

  • A key accidental experiment involving mixed genotypes led to the identification of enzyme deficiencies in Hurler and Hunter syndromes.
  • This serendipitous finding advanced the understanding of lysosomal enzyme biochemistry and receptor-mediated endocytosis.
  • The research facilitated the development of enzyme replacement therapy using recombinant enzymes.

Key Insights:

  • Identified specific enzyme deficiencies in Hurler and Hunter syndromes through a cell-mixing experiment.

More Related Videos

The Adventures of Fundi Intervention Based on the Cognitive and Emotional Processing in Attention Deficit Hyperactive Disorder Patients
05:48

The Adventures of Fundi Intervention Based on the Cognitive and Emotional Processing in Attention Deficit Hyperactive Disorder Patients

Published on: June 12, 2020

Related Experiment Videos

Last Updated: Jun 1, 2026

Using Visual and Narrative Methods to Achieve Fair Process in Clinical Care
14:32

Using Visual and Narrative Methods to Achieve Fair Process in Clinical Care

Published on: February 16, 2011

The Adventures of Fundi Intervention Based on the Cognitive and Emotional Processing in Attention Deficit Hyperactive Disorder Patients
05:48

The Adventures of Fundi Intervention Based on the Cognitive and Emotional Processing in Attention Deficit Hyperactive Disorder Patients

Published on: June 12, 2020

  • Elucidated the general biochemistry of lysosomal enzymes and the cell biology of lysosomal targeting.
  • Pioneered enzyme replacement therapy for mucopolysaccharide storage disorders.

    • Outlook:

    • Recent work at UCLA explores unexpected findings in Sanfilippo syndrome, a neurodegenerative disorder.
    • These findings hold significant implications for developing novel therapeutic strategies for Sanfilippo syndrome.
    • Continued research aims to refine and expand therapeutic approaches for various mucopolysaccharide storage diseases.