Related Experiment Video
Updated: Jun 1, 2026

Dried Blood Spots - Preparing and Processing for Use in Immunoassays and in Molecular Techniques
Published on: March 13, 2015
Space-time pattern of hepatitis A in Spain, 1997-2007
D Gomez-Barroso1, C Varela, R Ramis
1CIBER en Epidemiología y Salud Pública, Spain. dgomez@isciii.es
Hepatitis A risk in Spain showed higher incidence along the Mediterranean coast between 1997-2007. Spatial analysis identified significant space-time clusters, highlighting areas needing targeted public health interventions for this notifiable disease.
Area of Science:
- Epidemiology
- Public Health
- Spatial Analysis
Background:
- Hepatitis A is a compulsory notifiable disease in Spain.
- Regional incidence rates of Hepatitis A vary across Spain.
- Understanding space-time patterns is crucial for surveillance.
Purpose of the Study:
- To analyze the space-time pattern of Hepatitis A risk at the municipal level in Spain.
- To identify global and local risk variations from 1997 to 2007.
- To apply spatial statistics for epidemiological surveillance.
Main Methods:
- Utilized standardized incidence ratio (SIR) for global risk estimation.
- Employed posterior probability (PP) for smoothed relative risk assessment.
- Applied the scan statistic method for local space-time cluster analysis.
Main Results:
- Highest Hepatitis A risk was concentrated in Mediterranean coastal regions.
- Significant PP values (>0.8) indicated elevated risk areas.
- The most likely identified cluster revealed a relative risk of 53.530.
Conclusions:
- Spatial statistics are valuable complementary tools for infectious disease surveillance.
- Identified high-risk areas require focused public health strategies.
- The study provides insights into Hepatitis A epidemiology in Spain.
Related Concept Videos
Hepatitis
Viral Hepatitis I: Introduction
Diseases of the Liver and Gallbladder
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not related to...
Yellow Fever
Infectious Diseases and Their Occurrence
Hepatic Drug Excretion: Enterohepatic Cycling
Post-release drugs and metabolites can be reabsorbed into the body from the intestine. For conjugated metabolites like glucuronides, reabsorption requires enzymatic hydrolysis by intestinal microflora. This...
