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Long-term Continuous EEG Monitoring in Small Rodent Models of Human Disease Using the Epoch Wireless Transmitter System
Published on: July 21, 2015
A novel implanted device to wirelessly record and analyze continuous intracranial canine EEG
Kathryn A Davis1, Beverly K Sturges, Charles H Vite
1Department of Neurology, University of Pennsylvania, United States; Penn Epilepsy Center, United States. Kathryn.Davis@uphs.upenn.edu
Epilepsy Research
|June 17, 2011
Summary
Canine epilepsy offers a new model for studying human epilepsy. Continuous intracranial electroencephalography (iEEG) monitoring revealed seizure patterns in dogs that resemble human partial onset epilepsy.
Area of Science:
- Neurology
- Veterinary Medicine
- Biomedical Engineering
Background:
- Naturally occurring epilepsy in dogs shares similarities with human epilepsy in clinical presentation, epidemiology, and response to therapy.
- Intracranial electroencephalography (iEEG) is a valuable tool for epilepsy research.
Purpose of the Study:
- To present results from continuous iEEG monitoring in dogs with epilepsy.
- To characterize intracranial seizure onset patterns in a canine model.
- To evaluate a novel implantable device for real-time seizure monitoring.
Main Methods:
- Continuous iEEG monitoring was performed in 6 dogs with naturally occurring epilepsy.
- A novel implantable device wirelessly linked to a portable processing unit was utilized.
- Seizure onset patterns were analyzed and compared to human epilepsy.
Main Results:
- Previously uncharacterized intracranial seizure onset patterns were identified in dogs.
- These canine seizure patterns closely resemble those observed in human partial onset epilepsy.
- The novel technology enabled real-time seizure evaluation in an ambulatory setting.
Conclusions:
- Canine epilepsy serves as a suitable model for testing antiepileptic devices and surgical approaches for human epilepsy.
- The developed technology provides a versatile platform for evaluating seizures and therapeutic responses in ambulatory subjects.
