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Native N-glycopeptide thioester synthesis through N→S acyl transfer

Bhavesh Premdjee1, Anna L Adams, Derek Macmillan

  • 1Department of Chemistry, University College London, 20 Gordon Street, London WC1H 0AJ, UK.

Bioorganic & Medicinal Chemistry Letters
|June 17, 2011
PubMed
Summary

This study shows that forming peptide thioesters using native N-glycopeptides is compatible with N→S acyl transfer. This method simplifies the synthesis of homogeneous glycoproteins, overcoming challenges with sugar moiety stability.

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