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Granulocyte-dependent Autoantibody-induced Skin Blistering
Published on: October 12, 2012
Nonsteroidal anti-inflammatory drugs-induced generalized fixed drug eruption: two cases
Serap Gunes Bilgili1, O Calka, A S Karadag
1Department of Dermatology, Yuzuncu Yil University Faculty of Medicine, Van, Turkey. drserapgunes@yahoo.com
Abstract:
Fixed drug eruption (FDE) is a drug-induced cutaneous reaction that occurs at the same site with each exposure to a specific medication and usually manifests as round or oval, sharply demarcated erythematous or edematous plaques. The exact mechanism is unknown. The most common causative agent is co-trimoxazole. Other major categories of causative agents of FDE include antibiotics, antiepileptics, and nonsteroidal anti-inflammatory drugs (NSAIDs). FDE usually causes localized eruptions and very rarely generalized lesions. We report two cases of developing generalized FDEs after exposure to diclofenac and naproxen.
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