Related Experiment Video
Updated: May 31, 2026
09:15
Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles
Published on: November 10, 2017
Associations between dietary patterns and LDL peak particle diameter: a cross-sectional study
Annie Bouchard-Mercier1, Ann-Marie Paradis, Gaston Godin
1Department of Food Science and Nutrition, Laval University, Quebec, Canada. marie-claude.vohl@fsaa.ulaval.ca
Journal of the American College of Nutrition
|June 17, 2011
Summary
Dietary patterns influence low-density lipoprotein-peak particle diameter (LDL-PPD), a cardiovascular disease risk factor. Adhering to a Prudent diet is associated with smaller LDL-PPD, while a Western diet shows a weaker inverse correlation.
Area of Science:
- Nutrition Science
- Cardiovascular Health
- Biochemistry
Background:
- Dietary patterns are crucial for assessing nutritional impacts on health.
- Low-density lipoprotein-peak particle diameter (LDL-PPD) is an emerging risk factor for cardiovascular disease (CVD).
Purpose of the Study:
- To investigate the association between distinct dietary patterns and LDL-PPD.
Main Methods:
- Cross-sectional study of 635 adults (18-55 years).
- Dietary patterns identified using factor analysis on food frequency questionnaire data: Western and Prudent patterns.
- LDL-PPD characterized by nondenaturing gradient gel electrophoresis.
Main Results:
- The Western pattern showed a negative correlation with LDL-PPD (p=0.039).
- The Prudent pattern exhibited a significant negative correlation with LDL-PPD after adjustments (r=-0.12204, p=0.0021).
- Significant differences in LDL-PPD were observed between the highest and lowest tertiles of the Prudent pattern (p=0.0015).
Conclusions:
- Dietary patterns, specifically Western and Prudent, are associated with LDL-PPD.
- Nutritional habits, as reflected by dietary patterns, can be evaluated for their effects on health status, particularly concerning CVD risk factors.
Related Concept Videos
01:26Atherosclerosis III: Management
Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
01:25Blood Studies for Cardiovascular System III: Serum Lipid Profile
Understanding serum lipids is crucial for maintaining cardiovascular health and preventing heart disease and stroke.
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
01:18Lipids: Dietary Sources and Requirements
Lipids are an essential component of a balanced human diet. Triglycerides, which make up the majority of dietary lipids, are found in both saturated fats—commonly present in meat, dairy products, and certain tropical plants like coconut, and hydrogenated oils such as margarine and baking shortenings (trans fats)—and unsaturated fats, which are abundant in seeds, nuts, olive oil, and most vegetable oils. The main sources of cholesterol include egg yolks, various meats and organ meats, shellfish,...
01:30Atherosclerosis I: Introduction
Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...
01:30Coronary Artery Disease I: Introduction
Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
01:29Cholesterol: Significance and Regulation
Although not a source of energy, cholesterol plays a significant role as a foundational structure for bile salts, steroid hormones, and vitamin D, as well as being a crucial component of plasma membranes. Approximately 15% of blood cholesterol is derived from our diet, with the remainder synthesized from acetyl CoA by the liver and intestines. Cholesterol is eliminated from the body through its conversion into bile salts, which are eventually discarded in the feces.
Considering cholesterol and...
Considering cholesterol and...