[Change in platelet aggregation and ATP secretion: is there an early prediction of antidepressive therapy? (preliminary report)]
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Updated: May 31, 2026

Turbidimetry on Human Washed Platelets: The Effect of the Pannexin1-inhibitor Brilliant Blue FCF on Collagen-induced Aggregation
Published on: April 6, 2017
Laszlo Peter1, Katalin Schweitzer, Gabor Kovacs
1Honvédkórház-állami Egészségügyi Központ, Pszichiátriai Osztály, Budapest, Hungary. lacipe@freemail.hu
Abstract:
The number of biomarkers has increased to a great extent in the last years, but we have no marker in practice to help in the diagnosis of depression or to estimate the effectiveness of therapy. In depression we can measure the activation and aggregation of platelets, and the parallel secretion of ATP. Antidepressive therapy decreases aggregation and leads to changes in the release of ATP as well. The aim of our study was to determine whether the change in ATP release in early stages can predict the effectiveness of antidepressive treatment.
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