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Related Concept Videos

Contact-dependent Signaling01:19

Contact-dependent Signaling

Contact-dependent signaling, as the name suggests, requires that communicating cells be in direct contact with each other. This is achieved either through receptor-ligand interactions or by specialized cytoplasmic channels that allow the flow of small molecules between cells. In animal cells, channels called gap junctions facilitate contact-dependent signaling in certain tissues, whereas, plasmodesmata perform a similar function in plants.
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A call for a new connectivity.

Hugh MacLeod1

  • 1Canadian Patient Safety Institute.

Healthcarepapers
|June 17, 2011
PubMed
Summary
This summary is machine-generated.

This commentary argues for breaking down siloed thinking in research and practice. Adopting systems thinking is crucial for effective knowledge generation, application, and evaluation.

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Area of Science:

  • Interdisciplinary Studies
  • Knowledge Management
  • Systems Thinking

Background:

  • Traditional research models often create silos between knowledge generation and application.
  • This separation hinders the holistic understanding and effective utilization of research findings.

Discussion:

  • The commentary critiques the linear model of research: researchers generate knowledge, practitioners use it, and researchers evaluate outcomes.
  • This siloed approach prevents the integration necessary for true systems thinking.

Key Insights:

  • Breaking down disciplinary and professional silos is essential for advancing scientific understanding.
  • Systems thinking offers a framework to overcome fragmented approaches in research and practice.

Outlook:

  • Encourages a shift towards collaborative, integrated models in scientific endeavors.
  • Promotes further dialogue on dismantling silos for more impactful research and practice.