Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Drug Accumulation During Multiple Dosing: Intermittent IV Infusions

Drug Accumulation During Multiple Dosing: Intermittent IV Infusions

Intermittent intravenous (IV) infusion is a method of drug administration where medications are delivered over short infusion periods followed by intervals of no drug delivery. This approach helps to prevent sustained high drug concentrations in the bloodstream, reducing the risk of adverse effects associated with prolonged exposure. Unlike continuous infusion, steady-state concentrations may not be achieved during a single dosing cycle but can be reached through repeated...

Drug Accumulation During Multiple Dosing: Repetitive IV Injections

Drug Accumulation During Multiple Dosing: Repetitive IV Injections

Calculating drug dosage and accumulation in multiple-dose regimens is crucial for achieving therapeutic efficacy while avoiding toxicity. This involves determining the plasma drug concentrations over time to optimize dosing schedules. The principle of superposition is fundamental in this process, allowing for the prediction of drug concentration in plasma following multiple doses based on single-dose data.The principle of superposition asserts that the plasma concentration-time curves from...

Opioid Analgesics: Synthetic and Semisynthetic Opioids

Opioid Analgesics: Synthetic and Semisynthetic Opioids

Synthetic and semisynthetic opioids are pivotal in pain management and tackling opioid addiction. Semisynthetic opioids, including morphinans (morphine derivatives), oxycodone, oxymorphone, hydrocodone, and hydromorphone, have improved pharmacokinetic profiles compared to morphine. Additionally, heroin and 6-MAM (6-Monoacetylmorphine) show better CNS penetration than morphine due to heightened lipid solubility. Hydromorphone, a potent opioid, undergoes hepatic metabolism to form the active...

Drug Delivery: Parenteral Route

Drug Delivery: Parenteral Route

The parenteral route is a critical method of drug administration. It delivers compounds directly into the systemic circulation and bypasses the gastrointestinal tract. This approach is particularly advantageous for drugs that exhibit poor absorption or instability when administered orally.
There are three primary parenteral routes: intravenous (IV), intramuscular (IM), and subcutaneous (SC). The IV route introduces the drug directly into the bloodstream, ensuring immediate action. The IM route...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

AI counseling agent for motivational interviewing: Conversational processes associated with change talk in emergency department patients.

Journal of substance use and addiction treatment·2026

Same author

TFG-Containing Fusions in Melanocytic Tumors: From Polymorphic Read-Through Transcripts to Oncogenic Kinase Fusions.

Journal of cutaneous pathology·2026

Same author

Immunometabolic remodeling of perivascular adipose tissue in murine lupus: implications for lupus vasculopathy.

bioRxiv : the preprint server for biology·2026

Same author

Developing a Clinically Practical Biomaterial Platform for Endogenous Liver Regeneration.

Gels (Basel, Switzerland)·2026

Same author

Legionella Pneumonia Associated With Rhabdomyolysis and Acute Renal Failure: A Case Report.

Cureus·2026

Same author

Waldenstrom Macroglobulinemia Leading to Cholestatic Liver Injury and Rapid Progression to Liver Failure.

ACG case reports journal·2026

Search research articles

Related Experiment Video

Updated: May 31, 2026

A Modified Method for Intrathecal Catheterization in Rats

A Modified Method for Intrathecal Catheterization in Rats

Published on: February 14, 2025

Persistent hiccups with continuous intrathecal morphine infusion.

Vivek Loomba¹, Mayank Gupta, David Kim

¹Department of Anesthesiology, Henry Ford Hospital, Detroit, MI 48202, USA. vivek.loomba@gmail.com

The Clinical Journal of Pain

|June 17, 2011

Summary

This summary is machine-generated.

Intrathecal (IT) morphine infusion can cause persistent hiccups. Substituting IT morphine with IT hydromorphone effectively resolved the hiccups in a patient receiving chronic pain management.

More Related Videos

Assessment of Morphine-induced Hyperalgesia and Analgesic Tolerance in Mice Using Thermal and Mechanical Nociceptive Modalities

Assessment of Morphine-induced Hyperalgesia and Analgesic Tolerance in Mice Using Thermal and Mechanical Nociceptive Modalities

Published on: July 29, 2014

Intracranial Pharmacotherapy and Pain Assays in Rodents

Intracranial Pharmacotherapy and Pain Assays in Rodents

Published on: April 9, 2019

Related Experiment Videos

Last Updated: May 31, 2026

A Modified Method for Intrathecal Catheterization in Rats

A Modified Method for Intrathecal Catheterization in Rats

Published on: February 14, 2025

Assessment of Morphine-induced Hyperalgesia and Analgesic Tolerance in Mice Using Thermal and Mechanical Nociceptive Modalities

Assessment of Morphine-induced Hyperalgesia and Analgesic Tolerance in Mice Using Thermal and Mechanical Nociceptive Modalities

Published on: July 29, 2014

Intracranial Pharmacotherapy and Pain Assays in Rodents

Intracranial Pharmacotherapy and Pain Assays in Rodents

Published on: April 9, 2019

Area of Science:

Neurology
Pain Management
Pharmacology

Background:

Intrathecal (IT) morphine is utilized for chronic pain management.
Hiccups are a potential adverse effect of opioid administration.

Observation:

A 44-year-old male patient developed intractable hiccups during IT morphine infusion therapy.
The hiccups persisted despite multiple non-pharmacological and pharmacological interventions.

Findings:

Substitution of IT morphine with IT hydromorphone led to complete resolution of the patient's hiccups.
This suggests a direct link between IT morphine and the development of persistent hiccups.

Implications:

Clinicians should consider IT morphine as a potential cause of persistent hiccups in patients.
Switching to alternative intrathecal opioids, such as hydromorphone, may be an effective management strategy.