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Updated: May 31, 2026

Drug-Induced Sleep Endoscopy (DISE) with Target Controlled Infusion (TCI) and Bispectral Analysis in Obstructive Sleep Apnea
Published on: December 6, 2016
Sodium oxybate-induced sleep driving and sleep-related eating disorder
Douglas McKay Wallace1, Tanisha Maze, Shirin Shafazand
1Department of Neurology, Sleep Medicine Division, University of Miami Miller School of Medicine, Miami, FL, USA. dwallace@med.miami.edu
Abstract:
Hypnosedative-induced complex behaviors have gained increased attention in recent years as a potential complication of benzodiazepines and benzodiazepine-receptor agonist use. Sodium oxybate (SO), the sodium salt of γ-hydroxybutyrate, an inhibitory neurotransmitter, has been associated with dose-dependent rates of somnambulism; however, there is limited information about complex motor behaviors with SO. We describe a patient with narcolepsy-cataplexy who experienced one episode of sleep-driving and at least two sleep-related eating episodes with therapeutic doses of SO.
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