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Updated: May 31, 2026

Synthesis of Information-bearing Peptoids and their Sequence-directed Dynamic Covalent Self-assembly
Published on: February 6, 2020
Functionalizable oligoprolines as molecular scaffolds
Yvonne A Nagel1, Michael Kuemin, Helma Wennemers
1Department of Chemistry, University of Basel, St. Johanns-Ring 19, CH-4056 Basel.
Abstract:
Azidoproline (Azp) containing oligoprolines are conformationally well-defined, helical molecular scaffolds that allow for facile functionalization. Within this article we describe the synthesis of Azp-containing oligoprolines and different strategies to introduce functional moieties. In addition, the influence of factors such as substituents at the y-position of proline as well as functional groups at the termini on the conformational stability of the molecular scaffolds are briefly presented.

