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Gβγ subunits inhibit Epac-induced melanoma cell migration

Erdene Baljinnyam1, Masanari Umemura, Mariana S De Lorenzo

  • 1Department of Cell Biology and Molecular Medicine, New Jersey Medical School-University of Medicine and Dentistry of New Jersey, 185 South Orange Avenue, Newark 07103, USA.

BMC Cancer
|June 18, 2011
PubMed
Summary

G-protein βγ subunits (Gβγ) inhibit Epac1-activated melanoma cell migration by modulating calcium (Ca2+) signaling. This crosstalk between Gβγ and Epac1 is crucial for regulating melanoma cell movement.

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