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Updated: May 31, 2026
09:28
Patient-derived Orthotopic Xenograft Models for Human Urothelial Cell Carcinoma and Colorectal Cancer Tumor Growth and Spontaneous Metastasis
Published on: May 12, 2019
SOX4 expression levels in urothelial bladder carcinoma.
Sezgin Gunes1, Zeynep Yegin, Yurdanur Sullu
1Department of Medical Biology and Genetics, Ondokuz Mayis University, Faculty of Medicine, 55139, Samsun, Turkey. sgunes@omu.edu.tr
Pathology, Research and Practice
|June 18, 2011
Summary
SOX4 gene expression is elevated in bladder cancer, suggesting its potential role in tumor development. This finding highlights SOX4 as a possible factor in bladder cancer tumorigenesis.
Area of Science:
- Oncology
- Molecular Biology
- Genetics
Background:
- SOX4 gene expression is elevated in various human cancers.
- SOX4 protein may influence apoptosis and tumorigenesis.
- The role of SOX4 in bladder cancer requires further investigation.
Purpose of the Study:
- To investigate SOX4 gene and protein expression levels in bladder cancer tissues.
- To determine the association between SOX4 expression and bladder cancer development.
Main Methods:
- Immunohistochemistry was used to detect SOX4 protein presence.
- Real-time PCR quantified SOX4 gene expression levels.
- Bladder tumor samples (n=57) and normal bladder biopsies (n=13) were analyzed.
Main Results:
- SOX4 gene expression was 2.2-fold higher in bladder tumors compared to normal tissue.
- Immunostaining confirmed significantly higher SOX4 protein levels in bladder tumors (P=0.001).
Conclusions:
- SOX4 gene expression is significantly upregulated in bladder cancer.
- SOX4 may play a role in the tumorigenesis of bladder cancer.
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