Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Drug Dosing: Obese Patients

Drug Dosing: Obese Patients

In the United States, obesity is a prominent concern. It is linked to heightened mortality rates due to increased occurrences of conditions such as hypertension, atherosclerosis, coronary artery disease, and diabetes compared to nonobese individuals. A patient is classified as obese if their actual body weight surpasses the ideal or desirable body weight by 20%, based on Metropolitan Life Insurance Company data. Ideal body weights consider average weights and heights for males and females...

Pharmacokinetics in Obese Patients: Drug Metabolism and Excretion

Pharmacokinetics in Obese Patients: Drug Metabolism and Excretion

Drug metabolism, a critical process in the liver, involves two primary phases: Phase I reactions and Phase II conjugation. Obesity introduces significant alterations in this metabolic process, primarily due to fatty infiltration of the liver, leading to conditions such as nonalcoholic fatty liver disease (NAFLD). This condition can modify the activities of both Phase I and II enzymes, impacting how drugs are metabolized in obese patients.Phase I metabolism sees variable effects across...

Pharmacokinetics in Obese Patients: Drug Absorption and Distribution

Pharmacokinetics in Obese Patients: Drug Absorption and Distribution

Obesity significantly alters the pharmacokinetic processes of drug absorption and distribution, presenting unique challenges in medical treatment. The increased fat tissue and decreased lean muscle in obese individuals can significantly affect how drugs are absorbed into the body and distributed across different tissues. This alteration can lead to variances in the effectiveness and safety of medications, necessitating adjustments in dosing or drug selection for obese patients.One notable...

Obesity

Obesity

The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in adipocytes...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Familial Generalized and Partial Lipodystrophies Due to Rare Biallelic Variants in <i>LMNA</i>.

International journal of molecular sciences·2026

Same author

Genotype-phenotype heterogeneity among patients with lipodystrophy harboring rare POLD1 variants.

The Journal of clinical endocrinology and metabolism·2026

Same author

Novel Homozygous Variants in CIDEC and WRN in a Young Female with Lipodystrophy and Thyroid Cancer.

International journal of molecular sciences·2026

Same author

Response to letter to the editor by Matsubara and colleagues.

Journal of clinical lipidology·2026

Same author

A recurrent ACAA2 variant causes a dominant syndrome of lipodystrophy, lipomatosis, infantile steatohepatitis, and hypoglycemia.

The Journal of clinical investigation·2025

Same author

Erratum. Gain of Function NOTCH3 Variants Cause Familial Partial Lipodystrophy Due to Activation of Senescence Pathways. Diabetes 2025;74:427-438.

Diabetes·2025

Search research articles

Related Experiment Video

Updated: May 31, 2026

Randomized Controlled Trial to Study the Acute Effects of Strength Exercise on Insulin Sensitivity in Obese Adults

Randomized Controlled Trial to Study the Acute Effects of Strength Exercise on Insulin Sensitivity in Obese Adults

Published on: December 1, 2023

High-volume exercise program in obese bariatric surgery patients: a randomized, controlled trial.

Meena Shah¹, Peter G Snell, Sneha Rao

¹Division of Nutrition and Metabolic Diseases, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, USA. meena.shah@utsouthwestern.edu

Obesity (Silver Spring, Md.)

|June 18, 2011

Summary

A high-volume exercise program (HVEP) is feasible for about half of bariatric surgery patients. This program improved physical fitness and reduced postprandial blood glucose levels, but did not impact weight regain.

More Related Videos

Multidisciplinary Approach to Obesity Management: A Case Report

Multidisciplinary Approach to Obesity Management: A Case Report

Published on: May 30, 2025

Sleeve Gastrectomy in Mice using Surgical Clips

Sleeve Gastrectomy in Mice using Surgical Clips

Published on: November 14, 2020

Related Experiment Videos

Last Updated: May 31, 2026

Randomized Controlled Trial to Study the Acute Effects of Strength Exercise on Insulin Sensitivity in Obese Adults

Randomized Controlled Trial to Study the Acute Effects of Strength Exercise on Insulin Sensitivity in Obese Adults

Published on: December 1, 2023

Multidisciplinary Approach to Obesity Management: A Case Report

Multidisciplinary Approach to Obesity Management: A Case Report

Published on: May 30, 2025

Sleeve Gastrectomy in Mice using Surgical Clips

Sleeve Gastrectomy in Mice using Surgical Clips

Published on: November 14, 2020

Area of Science:

Bariatric surgery outcomes
Exercise physiology
Obesity management

Background:

Weight regain is a significant challenge for many patients following bariatric surgery.
The feasibility of implementing a high-volume exercise program (HVEP) in this population remains largely unexplored.

Purpose of the Study:

To determine the feasibility of an HVEP in obese patients who have undergone Roux-en-Y gastric bypass (RYGB) or gastric banding (GB) surgery.
To assess the impact of an HVEP on physical fitness and metabolic markers in post-bariatric surgery patients.

Main Methods:

33 obese post-bariatric surgery patients (mean BMI 41 ± 6 kg/m2) were randomized into HVEP or control groups for 12 weeks.
The HVEP group aimed for ≥ 2,000 kcal/week in moderate-intensity exercise, alongside energy intake counseling.
Treatment effects were evaluated using repeated measures analysis, focusing on physical activity, cardiorespiratory fitness, and metabolic parameters.

Main Results:

Approximately 53% of the HVEP group met the ≥ 2,000 kcal/week target, with 82% expending ≥ 1,500 kcal/week in the final 4 weeks.
Significant improvements were observed in the HVEP group for step count, moderate physical activity, maximal oxygen consumption, and reduced postprandial glucose levels compared to controls.
No significant differences were found between groups in weight change, energy/macronutrient intake, resting energy expenditure, or lipid and insulin concentrations.

Conclusions:

A high-volume exercise program is feasible in approximately 50% of post-bariatric surgery patients.
HVEP effectively enhances physical fitness and improves postprandial glycemic control in this patient group.
While HVEP shows benefits in fitness and glucose control, its impact on weight regain requires further investigation.