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Graphene oxide-peptide conjugate as an intracellular protease sensor for caspase-3 activation imaging in live cells

Haibo Wang1, Qing Zhang, Xia Chu

  • 1State Key Laboratory of Chemo/Bio-Sensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha, China.

Angewandte Chemie (International Ed. in English)
|June 18, 2011
PubMed
Abstract

No abstract available in PubMed .

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Caspases01:24

Caspases

Caspase, a family of cysteine proteases, serve as effectors in apoptosis. The ced3 gene in C.elegans was first identified to be involved in apoptosis. This gene encodes the ced-3 caspase that is similar to the interleukin-1-beta converting enzyme or ICE in mammals. In addition to apoptosis, caspases also function in the inflammatory response. Inflammatory caspases are essential in activating pro-inflammatory cytokines that recruit immune cells and block the replication of pathogens inside cells.

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