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Related Experiment Video

Updated: May 31, 2026

Intravitreal Injection and Quantitation of Infection Parameters in a Mouse Model of Bacterial Endophthalmitis

Intravitreal Injection and Quantitation of Infection Parameters in a Mouse Model of Bacterial Endophthalmitis

Published on: February 6, 2021

Elevated intraocular pressure is a common complication during active microbial keratitis.

Siamak Zarei-Ghanavati¹, Elmira Baghdasaryan, Arturo Ramirez-Miranda

¹Jules Stein Eye Institute, University of California, Los Angeles, 90095, USA.

American Journal of Ophthalmology

|June 21, 2011

Summary

Elevated intraocular pressure (IOP) during microbial keratitis is common, affecting 28% of patients. This condition is linked to poorer visual outcomes and increased need for surgery, highlighting the importance of regular IOP monitoring.

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Area of Science:

Ophthalmology
Infectious Diseases

Background:

Microbial keratitis is a serious eye infection that can lead to vision loss.
Intraocular pressure (IOP) changes can occur during active keratitis, but their impact is not fully understood.

Purpose of the Study:

To investigate the incidence, risk factors, and outcomes associated with elevated intraocular pressure (IOP) in patients with active microbial keratitis.

Main Methods:

A retrospective cohort study included 184 patients with culture-proven microbial keratitis.
High IOP was defined as ≥22 mm Hg during active infection.
Risk factors, microbial profiles, surgical needs, resolution time, and visual acuity were compared between high IOP and control groups.

Main Results:

Elevated IOP occurred in 28% of patients, with a mean of 29.1 mm Hg.
Prior ocular surgery, diabetes, and larger ulcer size (≥4.0 mm) were risk factors for high IOP.
High IOP was associated with increased need for surgery (39% vs. 11%), longer resolution time (50.1 vs. 31.6 days), and worse final visual acuity (20% vs. 47% achieving 20/40 or better).

Conclusions:

Elevated IOP is a significant finding in a substantial proportion of microbial keratitis cases.
High IOP is associated with adverse outcomes, including greater surgical intervention and poorer visual acuity.
Routine IOP monitoring is recommended in patients with active microbial keratitis to prevent potential optic nerve damage.