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Updated: May 31, 2026

Bladder Smooth Muscle Strip Contractility as a Method to Evaluate Lower Urinary Tract Pharmacology
Published on: August 18, 2014
Nonvoiding activity of the guinea pig bladder.
Bart T Biallosterski1, Gommert A van Koeveringe, Philip E van Kerrebroeck
1Department of Urology, Maastricht University Medical Centre and European Graduate School of Neuroscience, Maastricht University, Maastricht, The Netherlands. biallosterski@hotmail.com
Nonvoiding bladder contractions increase in frequency and amplitude with bladder filling in guinea pigs. These findings in anesthetized animals suggest different afferent activities during bladder filling may influence bladder pathology.
Area of Science:
- Urology
- Physiology
Background:
- Detrusor nonvoiding contractions are common in healthy individuals.
- These contractions can increase in pathological conditions and may involve afferent activity.
Purpose of the Study:
- To examine nonvoiding contractions in anesthetized guinea pig bladders.
- To investigate the effects of filling rate and intravesical volume on these contractions.
Main Methods:
- 14 guinea pigs were anesthetized and underwent bladder catheterization.
- Continuous infusion at two rates (25 and 50 μl/min) or isovolumetric cystometry with incremental filling was performed.
Main Results:
- Nonvoiding contractions were observed in all animals, increasing in frequency and amplitude with bladder filling.
- Distinct phases of contraction activity were identified, with small and large contractions showing different frequency patterns.
- Higher filling rates and intravesical volumes resulted in increased contraction frequency and amplitude.
Conclusions:
- Nonvoiding contractions are present in anesthetized guinea pigs and increase with filling rate and volume.
- Differences in small and large nonvoiding contractions suggest varying afferent activity during bladder filling.
- These findings may be crucial for understanding the mechanisms underlying bladder pathology.
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