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Updated: May 31, 2026

Genome-Wide Analysis of DNA Methylation in Gastrointestinal Cancer
07:50

Genome-Wide Analysis of DNA Methylation in Gastrointestinal Cancer

Published on: September 18, 2020

Intrinsic subtypes of gastric cancer, based on gene expression pattern, predict survival and respond differently to

Iain Beehuat Tan1, Tatiana Ivanova, Kiat Hon Lim

  • 1Department of Medical Oncology, National Cancer Centre Singapore, Singapore.

Gastroenterology
|June 21, 2011
PubMed
Summary

New genomic subtypes of gastric cancer (GC) were identified, showing distinct survival outcomes and chemotherapy responses. This intrinsic classification may personalize GC treatment and prognosis.

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Gene Regulation and Targeted Therapy in Gastric Cancer Peritoneal Metastasis: Radiological Findings from Dual Energy CT and PET/CT
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Published on: January 22, 2018

Area of Science:

  • Genomics
  • Cancer Biology
  • Molecular Oncology

Background:

  • Gastric cancer (GC) is a heterogeneous disease with varied biological properties and patient outcomes.
  • Identifying intrinsic subtypes is crucial for understanding GC heterogeneity.
  • Previous classifications did not fully capture GC's molecular diversity.

Purpose of the Study:

  • To identify novel intrinsic subtypes of gastric cancer using gene expression analysis.
  • To validate these subtypes in primary tumors and assess their association with patient survival.
  • To evaluate the relationship between intrinsic subtypes and response to standard chemotherapy drugs.

Main Methods:

  • Gene expression profiling of 37 GC cell lines to identify intrinsic subtypes.
  • Validation of subtypes in 521 primary tumors across 4 cohorts using expression profiling and immunohistochemistry (LGALS4, CDH17).
  • In vitro assessment of cell line sensitivity to 5-fluorouracil, cisplatin, and oxaliplatin.

Main Results:

  • Two major intrinsic genomic subtypes (G-INT and G-DIF) were identified with distinct gene expression patterns.
  • Intrinsic subtypes, unlike Lauren's classification, were prognostic for survival in multiple patient cohorts.
  • G-INT cell lines showed differential sensitivity to chemotherapy: more sensitive to 5-fluorouracil and oxaliplatin, but more resistant to cisplatin.
  • Intrinsic subtypes correlated with survival following 5-fluorouracil-based adjuvant therapy in patients.

Conclusions:

  • Intrinsic gastric cancer subtypes, defined by gene expression patterns, are linked to patient survival.
  • These subtypes predict response to chemotherapy, suggesting potential for tailored treatment strategies.
  • Classification based on intrinsic subtypes could improve GC prognosis and personalize therapeutic approaches.