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Published on: March 29, 2018
Orofacial granulomatosis associated with hypersensitivity to dental amalgam
Milan Tomka1, Alena Machovcová, Daniela Pelclová
1Institute of Dental Research, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic. tomka@vus.cz
Abstract:
Orofacial granulomatosis is a clinicopathologic entity characterized by chronic swelling of the lip and possible soft tissues in the orofacial region owing to granulomatous inflammation of unknown cause. We present 3 cases of orofacial granulomatosis associated with allergic contact dermatitis to dental materials. Previous treatment with corticosteroids did not have any therapeutic effect. Patch testing revealed a positive reaction to several allergens, including dental amalgam and mercury in 2 cases. A lymphocyte transformation test modified for metals was used to evaluate lymphocyte reactivity. After the removal of the suspected allergens, all patients experienced recovery within 1 month, with the exception of the lip swelling, which gradually subsided over several months.
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