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Updated: May 31, 2026

A Protocol for Computer-Based Protein Structure and Function Prediction
16:41

A Protocol for Computer-Based Protein Structure and Function Prediction

Published on: November 3, 2011

Structure-based prediction reveals capping motifs that inhibit β-helix aggregation.

Allen W Bryan1, Jennifer L Starner-Kreinbrink, Raghavendra Hosur

  • 1Harvard-Massachusetts Institute of Technology (MIT) Division of Health Sciences and Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA.

Proceedings of the National Academy of Sciences of the United States of America
|June 21, 2011
PubMed
Summary

The parallel beta-helix (β-helix) protein fold, common in many organisms, has capping structures that prevent aggregation. Removing these caps increases protein clumping, similar to amyloid formation.

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