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Related Concept Videos

Protein Complexes with Interchangeable Parts01:57

Protein Complexes with Interchangeable Parts

Groups of proteins may form a complex where each protein in this complex has a different role in the overall execution of the complex’s function. Often some of the proteins in the complex can be replaced by a closely related variant to give a complex that contains many of the same components yet is functionally distinct.
The SCF ubiquitin ligase is a protein complex of five individual proteins. This complex attaches ubiquitin to other target proteins to mark them for degradation. In order to...
Protein Complexes with Interchangeable Parts01:57

Protein Complexes with Interchangeable Parts

Groups of proteins may form a complex where each protein in this complex has a different role in the overall execution of the complex’s function. Often some of the proteins in the complex can be replaced by a closely related variant to give a complex that contains many of the same components yet is functionally distinct.
The SCF ubiquitin ligase is a protein complex of five individual proteins. This complex attaches ubiquitin to other target proteins to mark them for degradation. In order to...
Assembly of Signaling Complexes01:30

Assembly of Signaling Complexes

Multiprotein signaling complexes are formed in a dynamic process involving protein-protein interactions at the cytoplasmic domain of transmembrane receptors or enzymatic and non-enzymatic proteins associated with the receptor. These complexes ensure the activation and propagation of intracellular signals that regulate cell functions.
Interaction domains in cell signaling
Interaction domains recognize exposed features of their binding partners containing post-translationally modified sequences,...
Cooperative Allosteric Transitions01:58

Cooperative Allosteric Transitions

Cooperative allosteric transitions can occur in multimeric proteins, where each subunit of the protein has its own ligand-binding site. When a ligand binds to any of these subunits, it triggers a conformational change that affects the binding sites in the other subunits; this can change the affinity of the other sites for their respective ligands. The ability of the protein to change the shape of its binding site is attributed to the presence of a mix of flexible and stable segments in the...
Cooperative Allosteric Transitions01:58

Cooperative Allosteric Transitions

Cooperative allosteric transitions can occur in multimeric proteins, where each subunit of the protein has its own ligand-binding site. When a ligand binds to any of these subunits, it triggers a conformational change that affects the binding sites in the other subunits; this can change the affinity of the other sites for their respective ligands. The ability of the protein to change the shape of its binding site is attributed to the presence of a mix of flexible and stable segments in the...
Cooperative Allosteric Transitions01:58

Cooperative Allosteric Transitions

Cooperative allosteric transitions can occur in multimeric proteins, where each subunit of the protein has its own ligand-binding site. When a ligand binds to any of these subunits, it triggers a conformational change that affects the binding sites in the other subunits; this can change the affinity of the other sites for their respective ligands. The ability of the protein to change the shape of its binding site is attributed to the presence of a mix of flexible and stable segments in the...

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  1. Home
  3. Switchcraft: A Programmatic Framework For Designing State-switching Proteins.
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  3. Switchcraft: A Programmatic Framework For Designing State-switching Proteins.

Related Experiment Video

Dynamic Light-Induced Protein Patterns at Model Membranes
07:10

Dynamic Light-Induced Protein Patterns at Model Membranes

Published on: February 23, 2024

SwitchCraft: A Programmatic Framework for Designing State-Switching Proteins.

Bowen Jing, Mihir Bafna, Anisha Parsan

    Arxiv
    |June 5, 2026

    View abstract on PubMed

    Summary
    This summary is machine-generated.

    Researchers developed SwitchCraft, a new computational framework for designing proteins that can switch between multiple states. This advance enables the creation of novel protein functions for biotechnology applications.

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    Mimicking the Function of Signaling Proteins: Toward Artificial Signal Transduction Therapy

    Published on: September 29, 2016

    Related Experiment Videos

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    Mimicking the Function of Signaling Proteins: Toward Artificial Signal Transduction Therapy
    12:24

    Mimicking the Function of Signaling Proteins: Toward Artificial Signal Transduction Therapy

    Published on: September 29, 2016

    Area of Science:

    • Protein engineering
    • Computational biology
    • Biotechnology

    Background:

    • Natural proteins exhibit complex functions through multistate mechanisms.
    • Current deep learning methods struggle with designing multistate proteins.

    Purpose of the Study:

    • Introduce SwitchCraft, a framework for designing state-switching proteins.
    • Enable rational design of proteins with switchable functions.

    Main Methods:

    • Utilized backpropagation through compositional design constraints.
    • Integrated structure prediction models for parameterization.
    • Developed a programmatic framework for protein design.

    Main Results:

    • Demonstrated success in silico on various state-switching functional primitives.
  • Showcased allosteric regulation of motifs and ligand discrimination.
  • Designed novel fluorescent biosensors for small molecules in silico.

    • Conclusions:

    • SwitchCraft offers a versatile approach to higher-order functional protein design.
    • This framework opens new possibilities for protein engineering and biotechnology.
    • The developed methods facilitate the creation of sophisticated protein-based tools.