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Updated: May 31, 2026
06:56
Isolation, Culture, and Adipogenic Induction of Stromal Vascular Fraction-derived Preadipocytes from Mouse Periaortic Adipose Tissue
Published on: July 21, 2023
Perivascular adipose tissue and vascular disease
Kathryn A Britton1, Caroline S Fox
1National Heart, Lung & Blood Institute's Framingham Heart Study, Framingham, MA, USA.
Clinical Lipidology
|June 21, 2011
Summary
Perivascular adipose tissue, surrounding blood vessels, negatively impacts vascular health, especially with increased adiposity. This review explores its anatomy, effects, quantification, and links to cardiometabolic disease.
Area of Science:
- Cardiovascular Biology
- Adipose Tissue Research
- Metabolic Health
Background:
- Perivascular adipose tissue (PVAT) is a distinct fat depot surrounding blood vessels.
- PVAT exerts local paracrine effects on vascular function.
- The impact of PVAT on vasculature is modulated by adiposity levels.
Purpose of the Study:
- To review the anatomy and pathophysiology of PVAT.
- To summarize experimental evidence of PVAT's adverse vascular effects.
- To discuss methods for PVAT quantification and its association with cardiometabolic disease.
Main Methods:
- Literature review of anatomical, pathophysiological, and experimental studies.
- Exploration of epidemiological data.
- Description of PVAT quantification techniques.
Main Results:
- PVAT exerts local paracrine effects on blood vessels.
- Increasing adiposity alters PVAT's influence on the vasculature.
- Experimental evidence supports PVAT's adverse vascular effects.
Conclusions:
- PVAT plays a significant role in local vascular regulation.
- Dysfunctional PVAT, particularly in obesity, contributes to vascular pathology.
- Further research into PVAT quantification and its epidemiological links is warranted for understanding cardiometabolic disease.
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