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Induction and Clinical Scoring of Chronic-Relapsing Experimental Autoimmune Encephalomyelitis
26:48

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Published on: July 4, 2007

Hashimoto's encephalopathy: an under diagnosed entity.

Anil Bhansali1, P Jayaprakash, Pinaki Dutta

  • 1Endocrinology, PGIMER, Chandigarh, 160012, India.

BMJ Case Reports
|June 21, 2011
PubMed
Summary
This summary is machine-generated.

A woman with Hashimoto's thyroiditis experienced neurological symptoms despite stable thyroid hormone treatment. High antibodies and a positive response to glucocorticoids suggest an autoimmune component to her neuropsychiatric issues.

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Area of Science:

  • Endocrinology
  • Neurology
  • Immunology

Background:

  • Hashimoto's thyroiditis is an autoimmune disease affecting the thyroid gland.
  • Levothyroxine is the standard treatment for hypothyroidism.
  • Neuropsychiatric symptoms can occur in autoimmune thyroid disease.

Purpose of the Study:

  • To describe a case of Hashimoto's thyroiditis with persistent neuropsychiatric manifestations.
  • To investigate the role of high anti-thyroid peroxidase antibodies.
  • To evaluate the efficacy of glucocorticoid treatment.

Main Methods:

  • Case report of a 60-year-old woman.
  • Assessment of thyroid function and antibody levels.
  • Monitoring of neuropsychiatric symptoms during levothyroxine and glucocorticoid therapy.

Main Results:

  • The patient presented with neuropsychiatric symptoms despite optimal levothyroxine dosage.
  • High anti-thyroid peroxidase antibody levels were detected.
  • Symptoms improved significantly with glucocorticoid treatment.

Conclusions:

  • Autoimmune processes may contribute to neuropsychiatric manifestations in Hashimoto's thyroiditis, even with adequate thyroid hormone replacement.
  • Glucocorticoid therapy can be effective in managing these symptoms.
  • Further research into the mechanisms linking autoimmune thyroiditis and neuropsychiatric disorders is warranted.