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Updated: May 31, 2026

5/6th Nephrectomy in Combination with High Salt Diet and Nitric Oxide Synthase Inhibition to Induce Chronic Kidney Disease in the Lewis Rat
Published on: July 3, 2013
Malignant hypertension complicated by acute renal failure
1Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Department of Nephrology, 197 Ruijin Er Road, Shanghai, 200025, China.
Abstract:
Malignant hypertension is closely associated with impairment of multiple organs, and renal dysfunction remains an important cause of morbidity and mortality in patients with malignant hypertension. The renal histopathological changes usually indicate malignant arteriolar nephrosclerosis (MANS) that is characterised by fibrinoid necrosis in small arteries. However, renal biopsies were not taken routinely in previous reports. We report an educational case of malignant hypertension caused by MANS leading to thrombotic microangiopathy (TMA).
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