Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Chronic Kidney Disease II: Clinical Manifestations

Chronic Kidney Disease II: Clinical Manifestations

Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...

Synthesis and Functions of Calcitonin

Synthesis and Functions of Calcitonin

Calcitonin, a vital polypeptide hormone, regulates calcium levels within body fluids. It is released by the parafollicular cells, also known as C cells, situated in the follicular epithelium of the thyroid gland. Calcitonin responds to fluctuations in blood calcium levels and the influence of gastrointestinal hormones like gastrin and cholecystokinin.
The exact mechanisms by which calcitonin operates in calcium homeostasis remain elusive, but its significance is evident in several vital...

Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT

Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT

Calcium-Scoring CT ScanA calcium-scoring CT scan, also known as coronary artery calcium (CAC) scan, detects calcium deposits in the coronary arteries. This test assesses the risk of coronary artery disease (CAD), which can lead to cardiovascular events such as angina, heart failure, and sudden cardiac arrest.A calcium-scoring CT scan is generally recommended for individuals at intermediate risk of CAD without symptoms. It includes:Men aged 40-75 and women aged 50-75: Especially those with a...

Skeleton and Calcium Homeostasis

Skeleton and Calcium Homeostasis

Calcium is not only the most abundant mineral in bone but also the most abundant mineral in the human body. Calcium ions are needed for bone mineralization, tooth health, heart rate regulation and strength of contraction, blood coagulation, the contraction of smooth and skeletal muscle cells, and the regulation of nerve impulse conduction. The average calcium level in the blood is about 10 mg/dL. When the body cannot maintain this level, a person will experience hypo or hypercalcemia.

Imaging Studies for Cardiovascular System III: X-Ray

Imaging Studies for Cardiovascular System III: X-Ray

The most common cardiovascular diagnostic test is an X-ray. It produces images of the heart, blood vessels, and adjacent structures.
Definition and Purpose
An X-ray, or radiograph, is a non-invasive method that uses ionizing radiation to take images of internal structures. It is mainly used in cardiac imaging to examine the heart, lungs, and major blood vessels, aiming to identify abnormalities in the heart's size, shape, and position, such as heart failure, congenital defects, and vascular...

Chronic Obstructive Pulmonary Disease-III: Symptoms and Complications.

Chronic Obstructive Pulmonary Disease-III: Symptoms and Complications.

Understanding the variety of primary symptoms and systemic complications that characterize chronic obstructive pulmonary disease (COPD) is crucial for healthcare professionals.
Symptoms of COPD can be classified as primary or systemic. Primary symptoms relate to reduced airflow, while systemic or extrapulmonary symptoms relate to COPD's broader impact on the body.
Primary Symptoms of COPD:

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Competing Benefits and Competing Hazards: The Benefit to Harm Balance in Individual Patients in Rational Therapeutics.

Drug safety·2024

Same author

Preventable deaths involving opioids in England and Wales, 2013-2022: a systematic case series of coroners' reports.

Journal of public health (Oxford, England)·2023

Same author

Effectiveness of biosimilar adoption within a UK tertiary hospital: 6-year follow-up.

British journal of clinical pharmacology·2023

Same author

Drug shortages. Part 1. Definitions and harms.

British journal of clinical pharmacology·2023

Same author

Drug shortages. Part 2: Trends, causes and solutions.

British journal of clinical pharmacology·2023

Same author

Antihypertensive treatment in people of very old age with frailty: time for a paradigm shift?

Journal of hypertension·2023

Search research articles

Related Experiment Video

Updated: May 31, 2026

Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation

Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation

Published on: May 31, 2016

Calciphylaxis associated with widespread pulmonary calcification.

Tarvinder Singh Dhanjal¹, Suresh B Babu, Gareth Beevers

¹City Hospital, University Department of Medicine, Dudley Road, Birmingham B18 7QH, UK.

BMJ Case Reports

|June 21, 2011

Summary

This summary is machine-generated.

This case study highlights calciphylaxis in a patient with Crohn's disease and end-stage renal failure, leading to severe vitamin D deficiency and hyperparathyroidism. Early diagnosis and high suspicion are crucial for this rare, often fatal, condition.

More Related Videos

A Semi-Automated and Reproducible Biological-Based Method to Quantify Calcium Deposition In Vitro

A Semi-Automated and Reproducible Biological-Based Method to Quantify Calcium Deposition In Vitro

Published on: June 2, 2022

Related Experiment Videos

Last Updated: May 31, 2026

Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation

Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation

Published on: May 31, 2016

A Semi-Automated and Reproducible Biological-Based Method to Quantify Calcium Deposition In Vitro

A Semi-Automated and Reproducible Biological-Based Method to Quantify Calcium Deposition In Vitro

Published on: June 2, 2022

Area of Science:

Nephrology
Endocrinology
Dermatology

Background:

Crohn's disease and end-stage renal failure can lead to severe vitamin D deficiency and secondary hyperparathyroidism.
Calciphylaxis is a rare but serious complication associated with these conditions.
Pulmonary vasculature calcification can be an early, non-specific sign of calciphylaxis.

Purpose of the Study:

To report a case of calciphylaxis in a patient with Crohn's disease and end-stage renal failure.
To emphasize the importance of early diagnosis and high index of suspicion for calciphylaxis.
To illustrate the clinical presentation and rapid progression of calciphylaxis.

Main Methods:

Case report of a patient with Crohn's disease and end-stage renal failure.
Clinical observation of disease progression, including pulmonary vasculature calcification and skin lesions.
Review of literature on calciphylaxis, vitamin D deficiency, and hyperparathyroidism.

Main Results:

The patient presented with severe vitamin D deficiency and hyperparathyroidism secondary to Crohn's disease and end-stage renal failure.
Calciphylaxis developed, initially presenting as pulmonary vasculature calcification.
Classic skin lesions confirmed the diagnosis, but the patient had a rapid, fatal outcome within 7 days of diagnosis.

Conclusions:

Calciphylaxis is an emerging condition with high morbidity and mortality.
A high index of suspicion is critical for the timely diagnosis and management of calciphylaxis.
This case underscores the complex interplay between inflammatory bowel disease, renal failure, and calciphylaxis.