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Updated: May 31, 2026

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Bilateral mesial temporal polymicrogyria: a case report.

Giorgi Kuchukhidze1, Raimund Helbok, Iris Unterberger

  • 1Department of Neurology, Innsbruck Medical University, Innsbruck, Austria.

BMJ Case Reports
|June 21, 2011
PubMed
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Polymicrogyria is a brain malformation characterized by an unusually folded cerebral cortex. This condition, identified via MRI, presents unique challenges in understanding cortical organization and thickness.

Area of Science:

  • Neuroscience
  • Developmental Biology
  • Radiology

Background:

  • Polymicrogyria is a congenital brain malformation.
  • It is characterized by abnormal development of the cerebral cortex.
  • This condition leads to an irregular brain surface with excessive small gyri.

Purpose of the Study:

  • To describe the morphological and radiological features of polymicrogyria.
  • To enhance understanding of cortical organization in this malformation.
  • To identify key diagnostic markers on magnetic resonance imaging.

Main Methods:

  • Morphological analysis of brain development.
  • Review of magnetic resonance imaging (MRI) findings in polymicrogyria cases.
  • Comparison of cortical thickness and gyral patterns.

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Main Results:

  • Polymicrogyria exhibits an irregular brain surface with numerous small, excessively folded gyri.
  • Cortical thickness is reduced overall, but may appear increased due to fused gyri.
  • MRI reveals abnormal gyral patterns, increased apparent cortical thickness, and an irregular cortical-white matter junction.

Conclusions:

  • Polymicrogyria represents a significant disruption in cortical organization.
  • Characteristic MRI findings aid in its diagnosis.
  • Further research is needed to understand the functional implications of these structural changes.