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Swimming Induced Paralysis to Assess Dopamine Signaling in Caenorhabditis elegans

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Published on: April 3, 2019

Recurring paralysis.

Hung-Wei Lin¹, Tom Chau, Chin-Sheng Lin

¹Tri-Service General Hospital, Department of Medicine, Number 325, Section 2, Cheng-Kung Road, Taipei, Neihu 114, Taiwan.

BMJ Case Reports

|June 21, 2011

Summary

This summary is machine-generated.

A case of sporadic periodic paralysis initially presented as hypokalemia, but paradoxically showed hyperkalemia during treatment. This highlights the importance of considering both conditions in periodic paralysis diagnosis.

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Area of Science:

Neurology
Endocrinology
Internal Medicine

Background:

Sporadic periodic paralysis (SPP) is a rare neuromuscular disorder.
Hypokalemic periodic paralysis (HPP) is a subtype characterized by low serum potassium.
Misdiagnosis can occur due to atypical presentations.

Purpose of the Study:

To report a unique case of SPP with paradoxical hyperkalemia during treatment.
To emphasize the diagnostic challenges in periodic paralysis.
To illustrate the importance of comprehensive electrocardiogram (ECG) interpretation.

Main Methods:

Clinical presentation of a 22-year-old male with sudden paralysis.
Laboratory investigations including serum potassium levels.
Treatment with intravenous potassium chloride (KCl), calcium gluconate, insulin, and loop diuretics.
ECG monitoring for cardiac manifestations.

Main Results:

Initial presentation with severe hypokalemia (1.6 mmol/L).
Paradoxical decrease in serum potassium during KCl infusion.
ECG findings suggestive of hyperkalemia despite initial hypokalemia diagnosis.
Confirmed diagnosis of hyperkalemia (6.9 mmol/L) and subsequent resolution with appropriate treatment.

Conclusions:

This case underscores the critical need for vigilant monitoring and re-evaluation in periodic paralysis.
ECG can reveal hyperkalemia even when serum potassium initially suggests hypokalemia.
Prompt recognition and management of both hypokalemia and hyperkalemia are vital for patient recovery.